Wisconsin Alumni Research Foundation

Samuel Poore

Justin C Williams

Kip A Ludwig

Angela Williams

Thomas J Richner

Sahil K Kapur

Sarah K Brodnick

Electrical stimulation of specific facial and lingual nerves creates a more sustained pulsatility activity compared to stimulation of other cranial nerves. Pulsatility of arteries has intrinsic time constraints related to the time for vasodilation/constriction and time to return to baseline (T) after electrical stimulation which may affect the pulsatility response. Control of temporal patterning and the stimulation waveform maximizes the physiological response to cerebral pulsatility and its resulting effects on cerebral spinal fluid penetration into the brain parenchyma for a multitude of therapeutic uses including clearing misfolded proteins and/or administered pharmacological agents, diluting endogenous neurochemical concentrations within the brain, and reducing non-synaptic coupling.

Penetration of cerebral spinal fluid into the brain parenchyma using temporally patterned neuromodulation

An osseointegrated neural interface (ONI) is provided for control of a prosthetic. The ONI includes an elongated, hollow rod having a first end receivable in an intramedullary cavity of a bone, a second end operatively connected to the prosthetic and an inner surface defining a cavity. An electrode is receiveable on a terminal end of a peripheral nerve and positionable within the cavity of the rod. The electrode being capable of sensing the neural signals generated by the peripheral nerve and stimulating the peripheral nerve. A recording/stimulation unit, receiveable within the cavity of the rod, records the neural signals from the peripheral nerve sensed by the electrode and transmits the signals to a controller operatively connected thereto. The controller controls operation of the prosthetic in response to the neural signals recorded by the recording unit. In addition, the controller receives stimulation signals from a sensor in the prosthetic and causes the electrode to stimulate the peripheral nerve via the recording/stimulation unit in response thereto.

Osseointegrated neural interface and method

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Madison, WI, United States of America

Samuel Poore