University of Massachusetts

Incyte Genomics, Inc.

University of California

Samuel P Sawan

W Dale Spall

Lyle J Arnold

Paul H Lee

Abdelhafid Talhi

Kenneth E Laintz

Fu-jung Kao

Hung Chang Lee

Craig M Taylor

L Dale Sivils

Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H N&mdash;(CH ) &mdash;SiX where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.

Polymer coated surfaces for microarray applications

A method of modifying a polymeric substrate, such as polyethylene terephthalate and nylon 66, imparts water repellency and lubricity, and provides the additional benefit of reducing the soiling of fabrics. The method includes combining the polymeric substrate with a dense or liquified gas, such as carbon dioxide or sulfur hexafluoride, and a fluorinated compound, such as a fluorinated polyether.

Modification of polymeric substrates using dense or liquified gases

The invention features polymers with increased order, and methods of making them featuring a dense gas.

Polymers with increased order

An enzymatic reaction system including a modified enzyme, and a dense gas system; modified enzymes; and methods of reacting modified enzymes in a dense gas system or liquid carbon dioxide.

Dense gas-compatible enzymes

A method for treating a plastic, such as polyethylene or polypropylene, to remove at least a portion of at least one contaminant includes combining the plastic with a supercritical medium, such as carbon dioxide or sulfur hexafluoride, whereby at least a portion of the contaminant dissolves in the supercritical medium. Alternatively, the plastic can be combined with a suitable liquid medium, such as carbon dioxide or liquid sulfur hexafluoride. At least a portion of the medium, containing the dissolved contaminant, is separated from the plastic, thereby removing at least a portion of the contaminant from the plastic.

Growing community of inventors

Tyngsborough, MA, United States of America

Samuel P Sawan