Boston Scientific Scimed, Inc.

Scimed Life Systems, Inc.

Samuel P Baldwin

Jianmin Li

Tim Harrah

Robert P Skribiski

Timothy Paul Harrah

Marcia S Buiser

The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.

Controlling resorption of bioresorbable medical implant material through dispersed responsive particles

Controlling resorption of bioresorbable medical implant material by application of microwave, ultrasound or radiofrequencies

Controlling resorption of bioresorbable medical implant material

Chemically cross-linked polymeric particles are formed using mechanical rather than chemical processes, facilitating production of small-diameter particles in a manner largely independent of the viscosity or density of the polymer. For example, an uncross-linked resin may be provided in particulate form, agglomerated, and compressed into a mass of a desired shape with a desired diameter, and subsequently cross-linked.

Forming a chemically cross-linked particle of a desired shape and diameter

Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequently contacting the beads with a structural polymer. After crosslinking of the structural polymer has taken place, the template polymer may be removed to form the finished microspheres.

Processes for manufacturing polymeric microspheres

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Newton, MA, United States of America

Samuel P Baldwin