Valcare, Inc.

Endologix, Inc.

Warsaw Orthopedic, Inc.

Micardia Corporation

John Wayne Cancer Institute

Sdgi Holdings, Inc.

Cardiodyne, Inc.

Valcare Medical, Inc.

Vertelink Corporation

Nuvasive Specialized Orthopedics, Inc.

Trimedyne, Inc.

Onset Medical Corporation

Other

University of Southern California

Ellipse Technologies, Inc.

Samuel M Shaolian

Thanh Van Nguyen

To Van Pham

Nadav Yellin

George P Teitelbaum

Jeffrey P Dumontelle

Gilbert Madrid

Shahram Moaddeb

Emanuel Shaoulian

Trinh Van Pham

Ross Tsukashima

Boaz Schwarz

Matan Gedulter

Marvin P Loeb

Michael R Henson

Maurice Buchbinder

Hung H Cao

Bret Taback

Shuki Porath

David Hoon

Victor S Packham

Scott Louis Pool

Richard S Rhee

Brian C Gray

Vincent Divino

Steven R Anderson

L Dean Crawford

Michael C Sherman

Raphael Benary

George F Kick

Myles S Douglas

Yoav Rozen

Jay Alan Lenker

Lehmann K Li

James Huntington Dabney

Edward J Nance

Joseph Bishop

Daniel Rapoport

Avraham Eftel

Tsahi Grimberg

Seth Foerster

Daniel Anderson

Frank Nguyen

M Frank Zeng

Jeffrey J Giba

Andrea Colli

Guy Rogel

Viktoria Protsenko

Hunt Dabney

Daniel C Anderson

Richard H Estes

Gerard Von Hoffmann

David Zarbatany

Vahid Saadatmanesh

Randall J Blair

Nicolas Jabbour

Vahid Saadat

Aviad Galler

Frank M Zeng

Guy Shimel

Shawn Moaddeb

Troy Thronton

Jason Tran

Vincent Yeh

Frank Shannon

Paul A Molloy

Ninh H Dang

Avi Eftel

Yoav Rosen

Rafi Ari

Danny Rappaport

Viktoria Protensko

Jay Lenker

Onnick Tchulluian

An annuloplasty ring is disclosed. The annuloplasty ring includes an outer tube, a plurality of anchors, and at least one synthetic leaflet. The synthetic leaflets are in mechanical communication with the annuloplasty ring at a plurality of points. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the annuloplasty ring to a heart valve of a patient.

Annuloplasty ring with posterior leaflet for minimally invasive treatment

A system and method of repairing a native chordae of a patient using an artificial chordae. The artificial chordae is inserted into the patient in a non-deployed configuration using a delivery system and is delivered to a desired position within the patient. An operator causes the artificial chordae to transition from the non-deployed configuration to a deployed configuration. The artificial chordae is anchored to a myocardium of the patient. The artificial chordae is attached to a leaflet of the native chordae at an attachment location and tuned to a desired tension.

Systems and methods for delivery of chordae replacement system

Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

Mitral or tricuspid repair systems with multi-directional anchors

Disclosed herein are various embodiments directed to a device for minimally invasive medical treatment. The device being a hollow tube with a first end, a second end, and one or more anchors configured to extend outward from the exterior of the hollow tube. The hollow tube having a plurality of cutouts on the exterior, wherein the cutouts allow the hollow tube to be flexible. Additionally, the hollow tube may have at least one snap mechanism configured to connect the first end and the second end together.

Devices and methods for the treatment of heart valve insufficiencies

Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow body member including a plurality of regions. Adjacent regions cooperate with one another to change the body member from an elongate insertion geometry to an annular operable geometry. Adjacent regions are coupled by a biasing element or a stepped connector to allow expansion to an expanded state and contraction to a contracted state in the annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the body member and having a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. An angled ring closure lock allows coupling of the ends of an annuloplasty ring at an apex of a D-shape annular operable geometry.

Percutaneous annuloplasty system with anterior-posterior adjustment

Systems and methods treat a heart valve using a magnetically adjustable annuloplasty ring attached to or near a cardiac valve annulus. A changing magnetic field may be used to selectively increase or decrease a circumference of, or otherwise modify the shape of, the implanted annuloplasty ring. The adjustable annuloplasty ring includes a tubular body member, one or more adjustable members, and an internal magnet within the tubular body member. The tubular body member and the one or more adjustable members form a ring shape. The internal magnet is configured to rotate in response to a rotating external magnetic field. The internal magnet is coupled to the one or more adjustable members to change a dimension of the ring shape as the internal magnet rotates. A system for treating a heart valve may include an external adjustment device having one or more external magnets to generate the rotating external magnetic field.

Adjustable implant system

A device for securing an article to a tissue may include a body, transitionable from a deployment state to a securing state, having a first portion, a second portion, and a medial portion therebetween. The first portion and the second portion may each have an end configured to pierce the tissue. The device in the deployment state may have a linearly extended or a U-shaped structure. In the securing state, the first portion may be embedded in the tissue and the medial portion may contact the article. A system for securing the article to the tissue may releasably engage the device while in the deployment state. A method for securing the article may include contacting the article with a tissue surface and releasing the device from the system so that the device, in the securing state, may anchor the article to the tissue.

Device, system, and method to secure an article to a tissue

An implantable valve replacement system for a cardiovascular valve may include an adjustable stabilizing ring. The stabilizing ring may be composed of a body member that is transitionable from an elongate insertion geometry to an annular operable geometry. The stabilizing ring may further include a plurality of anchors deployable in the annular operable geometry to engage the annulus of the cardiovascular valve. The ring may be used in conjunction with an implantable valve frame. The valve frame may be located within the ring and the ring, in turn, may be stabilized through the anchors engaging the valve annulus. The valve replacement system may be applied by engaging the ring in its annular operable geometry with the valve annulus through the anchors. The valve frame may be inserted through the opening of the ring, thereby forming a stabilizing mechanical contact between the frame and the annulus.

Transcatheter bio-prosthesis member and support structure

Heart and peripheral vascular valve replacement in conjunction with a support ring

Disclosed herein is a delivery system for percutaneous heart valve repair, the delivery system including a steerable sheath configured to provide percutaneous access into a heart and to deliver an implant. The system may also have a steering mechanism configured to manipulate and orient the implant, a ball joint mechanism configured to connect the steerable sheath to the steering mechanism, a main knob assembly configured to advance and retract a multilumen shaft assembly, a stabilizing tool including a plurality of prongs configured to engage the implant within the heart to make an intimate contact with the heart tissue using a stabilizer and a tongue assembly, and a back assembly including: the actuation mechanism, a suture routing mechanism, a tip lock mechanism, and a back cover configured to protect all sutures being cut by mistake.

Device and method for delivery of an implant through a catheter

Apparatus, systems, and methods are provided for percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer tube, an inner body member, and an anchor deployment system. The outer tube includes a plurality of windows and has an axis along its length. The internal body member includes a plurality of anchors formed perpendicular to the axis. The anchor deployment system selectively rotates the internal body member with respect to the axis of the outer tube. The rotation deploys the plurality of anchors through the plurality of windows.

Methods, devices, and systems for percutaneously anchoring annuloplasty rings

Disclosed herein are embodiments related to a method for performing a minimally invasive procedure, the method including delivering an annuloplasty ring in a linear shape using a delivery system. In some embodiments, the delivery of the annuloplasty ring may utilize a trans-septal approach or a trans-apical. In some embodiments, the delivery system may position the annuloplasty ring using a flexible stabilizing mechanism and/or activate one or more anchors to extend outward from the annuloplasty ring.

Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system

Growing community of inventors

Newport Beach, CA, United States of America

Samuel M Shaolian