Mayo Foundation for Medical Education and Research

Aegis Medical Innovations Inc.

Biosig Technologies, Inc.

Boston Scientific Scimed, Inc.

Cardiac Pacemakers, Inc.

Anumana, Inc.

Sanovas Intellectual Property, LLC

St. Anne's University Hospital Brno

Cardiothrive, Inc.

Samuel J Asirvatham

Paul A Friedman

Charles J Bruce

Christopher V DeSimone

David R Holmes, Iii

Suraj Kapa

Mark B Knudson

Elliot Y K Hong

Trevor A McCaw

James P Rohl

Thomas George Foxall

Budimir S Drakulic

Branislav Vlajinic

Sina Fakhar

Barham K Abu Dayyeh

Kalpathi L Venkatachalam

Sarah Melissa Gruba

Douglas Dean Pagoria

Itzhak Zachi Attia

James A Klos

Francisco Lopez-Jimenez

Peter A Noseworthy

Murali Aravamudan

Joel T Eggert

Kevin E Bennet

Virend K Somers

Sudhir Kushwaha

Ajit Rajasekharan

David R Wulfman

John M Edgell

Douglas M Raymond

Venkataramanan Soundararajan

Arjun D Sharma

Shelley J Savage

Walter T Savage

Peter M Pollak

Gurpreet S Sandhu

Peter D Gray

Adeniyi O Aremu

Bryan Lester Striemer

Todd College

Douglas Pennington

Tyler Wagner

Benn Horrisberger

Matthew Hein

Barry A Borlaug

Arshad Jahangir

Bernard B C Lim

Vojtech Melenovsky

Christopher J McLeod

Michael J Ackerman

Pavel Leinveber

Miroslav Novak

Navtej S Buttar

Chance M Witt

Louis-Michel Wong Kee Song

Douglas S Beinborn

Faisal F Syed

John J Dillon

Tomas Kara

Zdenek Starek

Jiri Wolf

Soon J Park

Samir Awasthi

Michael J Levy

Lance Adam Freeseman

Bo Qiang

Douglas L Packer

Vaclav Kremen

Dorothy J Ladewig

Clark C Otley

Katherine Carlson

Corinne Carpenter

Elizabeth Rajan

Gianrico Farrugia

Juliane Bingener-Casey

Charanjit S Rihal

Ammar M Killu

Prakriti Gaba

Jennifer L Dugan

Dan Dragomir Daescu

Deepak Padmanabhan

Niyada Naksuk

Spencer A Bezalel

Christian Lee Baum

Alan M Sugrue

Hilary M Dubrock

Craig E Daniels

Mohamad A Alkhouli

Sudhir S Kushwaha

Susan B Johnson

Christopher J Mcleod

Jr David R Holmes

Ammar Killu

Bernard BC Lim

An example medical system for ablating and occluding the left atrial appendage is disclosed. The example system includes a catheter sized and shaped for vascular access and including an elongate body extending between a proximal end and a distal end. A first expandable member may be positioned near the distal end of the elongate body and have a first region configured to permeate a liquid therethrough. A first set of one or more electrodes may be arranged within the first expandable member and may be configured to deliver energy to the tissue region. An occlusive implant may be releasably secured to the distal end of the elongate body.

Ablation and occlusive system

Devices and methods can be used to treat heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Devices and methods for ablation of tissue

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

Electroporation for obesity or diabetes treatment

This document relates to devices and methods for the treatment of heart conditions. For example, this document provides devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.

Pericardial modification systems and methods for heart failure treatment

A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.

Method and apparatus for percutaneous epicardial ablation of cardiac ganglionated plexi without myocardial injury

Cystic lesions can be treated by electroporation. For example, this document describes methods and devices for endoscopic ultrasound-guided ablation of cystic lesions using a needle for electroporation.

Endoscopic ultrasound electroporation

Provided herein are methods, systems, and computer program products for the detection of pulmonary hypertension comprising receiving voltage-time data of a plurality of leads of an electrocardiograph of a subject; generating a feature vector from the voltage-time data; providing the feature vector to a pretrained learning system; and receiving from the pretrained learning system an indication of the presence or absence of pulmonary hypertension in the subject.

Noninvasive methods for detection of pulmonary hypertension

Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.

Methods and systems for electroporation

This document describes methods and materials for the treatment of pathological conditions, including arrhythmias and trauma, using temperature modulation via implantable devices. For example, this document relates to methods and devices for treating atrial and/or ventricular fibrillation by cooling the epicardium.

Systems and methods for implantable devices

This document describes methods and devices for securing epicardial devices. For example, this document describes methods and devices for securing epicardial devices by passing a sheath into a pericardial space of a patient through a first percutaneous access site, passing a guidewire through the sheath into the pericardial space of the patient, passing the guidewire through a transverse sinus of the patient, passing a snare device into the pericardial space through a second percutaneous access site, and capturing a free end portion of the guidewire using the snare device.

Methods and devices for securing epicardial devices

Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.

Thermal modification to treat cardiac electrical disorders and other disorders

Devices and methods for the treatment of heart conditions, and other medical purposes, include cardiac pacing systems. For example, this document describes temporary transvenous endocardial pacemaker systems and devices for deploying such systems without the need for conventional imaging procedures.

Temporary pacemaker systems and deployment systems

A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

Wearable device with tragus modulation system

Growing community of inventors

Rochester, MN, United States of America

Samuel J Asirvatham