The General Hospital Corporation

Harvard College

University of Washington

Samuel I Miller

John J Mekalanos

Toni Beth Kline

Heather B Felise

A method for inhibiting Gram-negative bacterial pathogenesis, a method of screening for compounds that inhibit type III secretion in Gram-negative bacteria, and compounds that inhibit type III secretion in Gram-negative bacteria.

5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection

Substantially pure Salmonella secreted proteins (Ssp), the sercetion of which is dependent upon the expession of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine strains in which Ssp secretion is decreased.

Salmonella secreted proteins and uses thereof

The invention features a Salmonella cell the virulence of which is attenuated by a deletion of a portion of the PhoQ gene and Salmonella cells having a deletion of the PhoQ gene and a deletion of the PhoP gene. The invention also features vaccines comprising such bacteria.

Growing community of inventors

Seattle, WA, United States of America

Samuel I Miller