Scil Technology Gmbh

Georgia Regents Research Institute, Inc.

Samuel Herberg

Wolfgang Friess

Cornelius Pompe

Klaus Hellerbrand

Michael Siedler

Andreas Schuetz

William D Hill

Sudharsan Periyasamy-Thandavan

Compositions and methods for modulating miRNAs up-regulated or down-regulated in aged individuals and their downstream targets are disclosed. Methods of treating musculoskeletal disorders are also provided.

Compositions and methods for treating musculoskeletal diseases and disorders

The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.

Biomaterial containing degradation stabilized polymer

The present invention relates to a polymer based material comprising a water binding agent, whereas the water binding agent is present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. It also relates to a polymer based material which comprises a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. Furthermore it relates to a method for manufacturing the polymer comprising material and use of the material for the preparation of a pharmaceutical composition to be used for treatment of bone, cartilage and/or periodontal defects. The invention also encompasses a kit using the polymeric material. Further, the present invention encompasses the use of a water binding agent for inhibiting water induced degradation of a polymer comprising material, for inducing blood clot stabilization in a polymer comprising material and for increasing storage stability in a polymer comprising material, wherein the water binding agent is not removed prior to application of the material.

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Augusta, GA, United States of America

Samuel Herberg