Eli Lilly and Company

Lilly Industries, Inc.

Samuel Dean Larsen

Charles A Bunnell

David Edward Tupper

Terrence M Hotten

Gregory Alan Stephenson

Susan M Reutzel

John Richard Nichols

Jeffrey Thomas Vicenzi

Brian Weston Dalder

Barry A Hendriksen

Sharon Van Den Berghe Snorek

Michael Anthony Dotlich

A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate, addition of an aldehyde derivatizing agent which interacts with an aldehyde impurity, addition of an acid/metal salt to form a solubilized echinocandin nucleus salt having the desired anion, and subsequent cooling of the mixture to crystallize the salt.

Formation and anion-exchange of crystalline echinocandin ammonium salts

The present invention provides the novel Dihydrate D 2-methyl-thieno-benzodiazepine and a formulation therefor.

Olanzapine dihydrate D

The present invention provides a process for preparing olanzapine and intermediates therefor.

Intermediates and process for preparing olanzapine

The invention provides Form II, a pharmaceutically elegant, stable polymorph of olanzapine useful for treating a condition selected from the group consisting of a psychotic condition, mild anxiety and gastrointestinal conditions.

Olanzapine polymorph crystal form

The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno�2,3-b!�1,5!benzodiazepine (olanzapine) and a process for making such lower alcohol solvates of olanzapine. The invention provides a method for using such solvates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.

Process and solvate of 2-methyl-thieno-benzodiazepine

The invention provides a methylene chloride solvate of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. The invention provides a method for using such solvate.

Solvate of olanzapine

The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) and a process for making such lower alcohol solyates of olanzapine. The invention provides a method for using such solyates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.

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West Lafayette, IN, United States of America

Samuel Dean Larsen