Barnes Jewish Hospital

Washington University

University of South Florida

Bristol-myers Squibb Medical Imaging, Inc.

The Dow Chemical Company

Philips Electronics North America Corporation

The Jewish Hospital of St. Louis

Samuel A. Wickline

Gregory M. Lanza

Samuel A Wickline

Gregory M Lanza

Hua Pan

Stuart A Solin

Kirk D Wallace

Michael S Hughes

Garry E Kiefer

Phillip S Athey

Paul H Schlesinger

Tom Harris

Neelesh R Soman

Dipanjan Pan

Gyongyi Gulyas

Akhil Maheshwari

Jacob Myerson

Akm Shah Newaz

Kirk Hou

Kopperuncholan Namachivayam

Mladen Victor Wickerhauser

Ruisheng Liu

Stefan E Fischer

Rohun Palekar

Christine H Lorenz

Jin Wei

Huimin Yan

Christine Thien-Nga Pham

Xin Yu

Frank Hockett

Christopher S Hall

Jie Zhang

John McCarthy

Angana Senpan

The present disclosure is directed to antithrombotic nanoparticles and methods of treating necrotizing enterocolitis.

Antithrombotic nanoparticles and methods for treating necrotizing enterocolitis

The present disclosure relates to nanoparticles and methods for polynucleotide transfection.

Peptide-polynucleotide-hyaluronic acid nanoparticles and methods for polynucleotide transfection

A targeting nanoparticle composition and method of treatment for diseases associated with major basement membrane components of blood vessels accessible from blood stream is presented. The composition includes pegylated perfluorocarbon nanoparticles having a targeting ligand attached that targets the basement membrane components, specifically collagen IV. The targeted nanoparticles may contain at least one pharmaceutically active agent capable of treating a glomerular disease such as lupus nephritis.

Nanoparticle delivery system for diseases associated with major basement membrane components of blood vessels accessible from blood stream

A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.

Peptide-polynucleotide complex for polynucleotide transfection

Compositions and methods for polynucleotide transfection

The present invention encompasses an antithrombotic nanoparticle and use thereof.

Antithrombotic nanoparticle

The present invention encompasses an antithrombotic nanoparticle.

The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents.

Ligand directed toroidal nanoparticles for therapy and diagnostic imaging

Disclosed herein is an apparatus comprising a metal shunt and a semiconductor material in electrical contact with the metal shunt, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to planes in which the semiconductor material and the metal shunt lie, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.

Multifunctional nanoscopy for imaging cells

The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent.

Particles for imaging

The present invention relates to methods for improving muscle strength and treating muscular dystrophy.

Methods for improving muscle strength

The inventors disclose a new high performance optical sensor, preferably of nanoscale dimensions, that functions at room temperature based on an extraordinary optoconductance (EOC) phenomenon, and preferably an inverse EOC (I-EOC) phenomenon, in a metal-semiconductor hybrid (MSH) structure having a semiconductor/metal interface. Such a design shows efficient photon sensing not exhibited by bare semiconductors. In experimentation with an exemplary embodiment, ultrahigh spatial resolution 4-point optoconductance measurements using Helium-Neon laser radiation reveal a strikingly large optoconductance property, an observed maximum measurement of 9460% EOC, for a 250 nm device. Such an exemplary EOC device also demonstrates specific detectivity higher than 5.06&#xd7;10cm&#x221a;Hz/W for 632 nm illumination and a high dynamic response of 40 dB making such sensors technologically competitive for a wide range of practical applications.

Method and apparatus for high resolution photon detection based on extraordinary optoconductance (EOC) effects

Disclosed herein is an apparatus comprising a metal shunt and a planar semiconductor material in electrical contact with the metal shunt, the metal shunt located on a surface of the semiconductor material, thereby defining a semiconductor/metal interface for passing a flow of current between the semiconductor material and the metal shunt in response to an application of an electrical bias to the apparatus, wherein a portion of that semiconductor material surface is not covered by the metal shunt, wherein the semiconductor material and the metal shunt lie in different planes that are substantially parallel planes, the semiconductor/metal interface thereby being parallel to the plane of semiconductor material, and wherein, when under the electrical bias, the semiconductor/metal interface is configured to exhibit a change in resistance thereof in response to a perturbation. Such an apparatus can be used as a sensor and deployed as an array of sensors.

Growing community of inventors

St. Louis, MO, United States of America

Samuel A Wickline