Elekta Ab (publ)

Elekta Neuromag Oy

Elekta Ab

Megin Oy

Samu Taulu

Juha T Simola

Juha Simola

Matti J Kajola

Lauri Parkkonen

Antti I Ahonen

Jukka Nenonen

Antti Ahonen

The present invention introduces a method, device and a computer program for removing artifacts present in individual channels of a multichannel measurement device. At first, a basis is generated defining an n-dimensional subspace of the N-dimensional signal space, where n is smaller than N, where using in the definition of the n-dimensional basis a physical model of a Signal Space Separation method, or a statistical model based on the statistics of recorded N-dimensional signals. Thereafter, a combined (n+m)-dimensional basis is formed by adding m signal vectors to the n-dimensional basis, each of these m signal vectors representing a signal present only in a single channel of the N-channel device. After this the recorded N-dimensional signal vector is decomposed into n+m components in the combined basis, and finally, components corresponding to the m added vectors in the combined basis are subtracted from the recorded N-dimensional signal vector.

Method and device for recognizing and removing undesired artifacts in multichannel magnetic field or electric potential measurements

The present invention introduces a method, apparatus and computer program for magnetic resonance imaging or magnetoencephalography applications in order to control currents of a coil assembly (), and thus achieving desired magnetic fields precisely in the measuring volume (). The approach is an algebraic method where a field vector is generated for the test currents of each coil (). Vector and matrix algebra is applied and a linear set of equations is formed. Field components and their derivatives up to the desired order can be taken into account. Principal component analysis or independent component analysis can be applied for determination of the dominant external interference components. By checking the condition value for the matrix (), it is possible to investigate whether a reasonable solution of currents for desired magnetic fields is possible to achieve. Finally, solved currents can be installed into a current supply unit () feeding the coils of the assembly (). The invention can be applied as an active compensation feature for different interference shapes in the MEG application (), or for the precise creation of the fields and gradients in the MRI application ().

Method for designing coil systems for generation of magnetic fields of desired geometry, a magnetic resonance imaging or magnetoencephalography apparatus with a coil assembly and a computer program

The present invention introduces a method for adjusting interference signal estimates provided by multichannel biomagnetic field measurements. A so-called Signal Space Separation method (SSS) is applied in the calculatory analysis of the measurement signals, providing for the division of the sources causing the fields in objects of interest and external interferences. When the signal basis representing the interferences has been estimated, this interference signal estimate is adjusted by measuring the fields without the object to be measured and without changing the sensor assembly. Interference components obtained in this manner are analyzed in such a way as to include only the most significant interference components. An adjusted interference subspace is formed, by means of which signal processing and the analysis of the useful signals can be continued.

Method for adjusting interference signal space in biomagnetic field measurements

The present invention introduces a method for processing multichannel measurement data achieved especially in MEG and EEG measurements. The method uses a signal space separation (SSS) method and the orthogonality of lead fields in order to calculate linear transformation from physical measurement channels to virtual channels. The geometry related to the measurement arrangement is dissipated and the number of virtual channels is clearly lower than the number of physical sensors. The concept of total information can be applied for such transformed measurement data due to orthogonality. The method offers simplified post-processing of the biomagnetic data, such as for source modelling. The total information can also be interpreted as a robust quantity describing the physiological state of a patient.

Analysis of multi-channel measurement data using orthogonal virtual channels

The present invention recognises and eliminates from a biomagnetic measurement signal interferences whose source is disposed in the direct vicinity of an object being measured. The invention utilises the SSS method that can be used to separate from one another the signals associated with the internal and external sources of a set of measurement sensors by calculating two series developments. The sources to be examined in the invention and disposed in the so-called intermediate space produce a component to both of the developments, and can, therefore, be detected by means of an analysis to be performed in a time domain. This division into components can be made using the Principal Component Analysis (PCA), the Independent Component Analysis (ICA) or the Singular Value Decomposition. Finally, the clarified interferences in the intermediate space can be eliminated from the measured signal using, for example, the linear algebraic orthogonal projection.

Method and device for interference suppression in electromagnetic multi-channel measurement

The present invention describes a method enabling one to shield a device that measures weak biomagnetic signals from strong magnetic interference fields. The measurement sensors are provided with a feedback compensation loop, the difference signal of which is obtained from the measurement sensors themselves. As the actuator of the feedback function, one or more coils are responsible for eliminating, the external interference fields in the region of the sensors. Difference signals can be generated as a linear combination from the signals of two or more sensors. In the control logic, the SSS method can be used to numerically separate the biomagnetic signal being measured from the signals produced by the sources&#x2014;compensation coils and interference sources&#x2014;disposed outside the measurement region. The interference suppression can be enhanced by placing the assembly of sensors and the actuators within a magnetically shielding room.

Method for interference suppression in a measuring device

A method for interpreting the current distribution of an object being measured using basis vector components calculated from the measured signals. The components in question have been so selected that they describe the features, as independent as possible, of the current distribution being examined, which enhances the computation and makes it more accurate. This is achieved by converting the measured signals into a more natural form from the standpoint of the current distribution while totally eliminating the signals associated with the external interferences. After the conversion, the source modeling is performed in an optimal manner using the basis vector components of the signal space instead of the actual measurement signals. One substantial feature of the invention is that after the conversion, the source model need not be regularized any more.

Method and device for using a multi-channel measurement signal in source modelling

A method and device by means of which an irrotational, sourceless vector field can be expressed by a number of physically reasonable basis vectors. In the method and device for processing a multi-channel measurement of magnetic fields of the present invention, measured signals can be unambiguously divided into signals of the irrotational, sourceless vector field that are caused by an interesting object or external interferences, as well as into a signal caused by the nonideality of the measuring device. The invention is based on the combining of two very fundamental mathematical regularities and applying in the processing of signal vectors of a multi-channel measuring device that measures an irrotational, sourceless vector field. The invention is based on the Maxwell's equations of an irrotational, sourceless vector field, as well as on the convergence characteristics of series developments.

Method and device for processing a multi-channel measurement of magnetic fields

The invention relates to a method and device by means of which the location and position of an object may be determined in relation to another object by electromagnetic signals. In the arrangement in accordance with the invention there are two objects to the one of which there are attached signal sources, i.e. transmitters that generate electromagnetic signals, and the other object contains one or more receivers for measuring the transmitter signals. Usually the object containing transmitters is the one whose location or position is of interest and which is the object of the measurement. For example, in MEG measurements the object associated with the transmitters is the head of a human being on whose surface the transmitters are placed. By means of the arrangement in accordance with the invention is possible to find out the location and position of the head, in which case the location of the signals generated by the brain may be found out and utilized when examining the brain activity. The transmitters are also used to measure the signals emanating from the brain.

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Helsinki, Finland

Samu Taulu