Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Samson M Jolly

Neville J Anthony

Robert P Gomez

Linghang Zhuang

Melissa S Egbertson

John S Wai

Thomas Joseph Tucker

Steven D Young

Dai-Shi Su

Mark W Embrey

Thorsten E Fisher

James P Guare

John T Sisko

Debra S Perlow

H Marie Langford

Jeffrey Y Melamed

John Jin Lim

Jennifer J Bennett

Michelle Sparks Kuo

Timothy W Funk

John Lim

Heteroaromatic compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein ring A is: (ii-a), (ii-b), (ii-c), (ii-d), or (ii-e); and wherein n, L, M, U, X, Y, Z, R, R, R, R, R, R, R, R, Rand Rare defined herein. The compounds of Formula I and their pharmaceutically acceptable salts and prodrugs are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts and prodrugs can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. 

Non-nucleoside reverse transcriptase inhibitors

N-(Sulfonyloxybiarylmethyl) aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors

Growing community of inventors

Collegeville, PA, United States of America

Samson M Jolly