Council of Scientific and Industrial Research

Samsher Singh

Ram Asrey Vishwakarma

Inshad Ali Khan

Ajay Kumar

Naresh Kumar Satti

Sandip Bibishan Bharate

Sanjay Rai Kumar

Prashant Joshi

Parvinder Pal Singh

Gurunadham Munagala

Sumit Sharma

Kushalava Reddy Yempalla

Umed Singh

Satish Sonbarao Gudup

Naresh Satti

Vishwakarma Ram Asrey

Hari Prasad Aruri

A pharmaceutical composition for the treatment of multi-drug resistant infections includes an antimicrobial agent in combination the benzopyrano[3,4-b][1]benzopyran-12(6H)-one class of compound boeravinone B of Formula 1: The bio-efficacy of anti-infective drugs can be potentiated, when used in combination with boeravinone B. Boeravinone B can overcome the resistance or multi-drug resistance developed by bacteria against quinolone, mupirocin and macrolide class of anti-bacterial agents via inhibition of bacterial efflux pumps. Thus, the compositions can be used to treat or prevent drug-resistant bacterial diseases.

Pharmaceutical composition for the treatment of multi-drug resistant infections

The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their method of preparation and their use as drugs for treatment of tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In general formula 1, X is selected from a group (CH)or a direct bond, where n is any number from 1-6, Y is selected from O, S or direct bond, Ris selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, biaryl, substituted biaryl, heterocyclic and substituted heterocyclic, wherein the substituted heterocyclic is selected from any of the following rings consisting of piperazinyl, morpholinyl, piperidyl, pyridyl, triazolyl, triazinyl, pyrimidinyl, pyridazinyl, oxazolyl, furanyl, benzofuranyl, thiophenyl, pyrrolyl, imidazoyl, thiazoyl, quinolinyl, isoquinolinyl, benzooxazolyl and benzothiazolyl and the substitution on aryl and biaryl is selected from the group consisting of F, CI, Br, I, CF, OCF, OR, NOand alkyl chain from C1 to C14, wherein Ris selected from the group consisting of H, alkyl, phenyl and substituted phenyl. 

Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof

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Jammu, India

Samsher Singh