Strides Shasun Limited

Shasun Pharmaceuticals Limited

Strides Pharma Science Limited

Sampathkumar Devarajan

Jeffrey Stuart Bergman

Selvakumar Ramalingam

Anandsenthil Vel Palanisamy

Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40&#xb0; C./75% RH) for 3 months in laminated tubes.

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Chennai, India

Sampathkumar Devarajan