Mayo Foundation for Medical Education and Research

Novartis Ag

Protagonist Therapeutics, Inc.

Vicuron Pharmaceuticals Inc.

Nanosyn, Inc.

Sampath-Kumar Anandan

Kevin Lloyd Greenman

Vijay Prem Singh

Zeeshan Kamal

Zachary Kevin Sweeney

Oliver L Saunders

Xiaodong Lin

Martijn Fenaux

Fumiaki Yokokawa

Liang Mao

Weidong Zhong

Virender Singh Aulakh

Dinesh Vinoobhai Patel

Ashok Bhandari

Mikhail Fedorovich Gordeev

Suresh Kumar Manthati

Jason G Lewis

Hardwin O'Dowd

Mukund M Mehrotra

Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.

Compounds for the reducing lipotoxic damage

The present invention provides methods of making &#x3b1;4&#x3b2;7 peptide monomer and dimer antagonists. Methods of the present invention include solid phase and solution phase methods, as well as synthesis via condensation of smaller peptide fragments. Methods of the present invention further include methods directed to the synthesis of peptides comprising one or more penicillamine residues.

Methods for synthesizing &#x3b1;4&#x3b2;7 peptide antagonists

The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R, R, R, R, Rand Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

2'-ethynyl nucleoside derivatives for treatment of viral infections

The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R, R, R, R, Rand Z are as defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

2'-Ethynyl nucleoside derivatives for treatment of viral infections

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin derivatives possessing antimicrobial activity

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Fremont, CA, United States of America

Sampath-Kumar Anandan