The University of Mississippi

R.p.scherer Technologies, Inc.

Sampada Bhaskar Upadhye

Michael Andrew Repka

Roshan Vijay Tiwari

Hemlata Gunga Patil

Joseph Thomas Morott, Jr

Jun-Bom Park

Wenli Lu

Ronald S Vladyka

Ronald S Vladyka, Rph

Joseph Thomas Morott

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Twin-screw dry granulation for producing solid formulations

Growing community of inventors

Princeton, NJ, United States of America

Sampada Bhaskar Upadhye