Council of Scientific and Industrial Research

Sampa Sarkar

Dhiman Sarkar

Swati Pramod Joshi

Roshan Rajan Kulkarni

Ketaki Dilip Shurpali

Preeti Madhukar Chaudhary

Sunita Ranjan Deshpande

Arshad Khan

Sayalee Ramchandra Chavan

Shailaja Pramod Maybhate

Anjali Prabhakar Likhite

Ramana Venkata Chepuri

Rahul Shivaji Patil

The present invention describes the use of pharmaceutical compositions including compounds of formula 2 (below) for treatment of infections related toand for anti-proliferative activity. Also, the present invention discloses a process of extraction of compounds of formula 2 from the extract of aerial parts of: 

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Disclosed herein is 10-&#x3b1;/&#x3b2;-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R&#x2033; are as defined herein in the specification. The present invention also discloses a simple stereoselective synthesis 10-&#x3b1;/&#x3b2;-D-Arabinofuranosylundecenes of Formula (II) to target enzymes involved in the biosynthesis of cell wall ofand thus useful as inhibitors in thedrug development. 

10-&#x3b1;/&#x3b2;-D-arabinofuranosyl-undecenes as potential anti-mycobacterial agents and process for the preparation thereof

This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same. 

C-9 oxygen functionalized labdane derivates

Triazole derivatives useful as anti-tubercular compounds; process for preparation of the triazoles and a method for inhibiting growth ofBCG andH37Ra using the triazoles.

1, 2, 4-triazole derivatives and their anti-microbial activity

Invention provides antitubercular compounds selected from propargylated 1,2,3 triazoles of Formula I, wherein, X is sulfur(S) or a sulphone (A), n, m represent independently an integer O or 1, with the provision that when 'n' is 1, 'm' is 1; R1 is hydrogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group; halogen; or aryl group optionally substituted with &#x2014;OCH3, halogen, and nitro; R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl allyl or propargyl groups consisting of 1 to 6 carbon atoms; with the provision that when &#x2018;m&#x2019; is 1, and &#x2018;n&#x2019; is zero; R1 is selected from the group consisting of hydrogen, halogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group or aryl group optionally substituted with &#x2014;OCH3, halogen, and nitro, R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is selected from the group consisting of halogen, C1-C6 linear or branched alkyl group optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, wherein the heterocyclic ring may further be substituted with halogen, alkyl, arylalkyl.

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Pune, India

Sampa Sarkar