Apotex Pharmachem Inc.

Other

Sammy Chris Duncan

Yajun Zhao

Bhaskar Reddy Guntoori

Daqing Che

Uma Kotipalli

Peter Garth Blazecka

Gamini Weeratunga

Stephen E Horne

Fan Wang

Cameron L McPhail

Kiran Kumar Kothakonda

Alfredo Paul Ceccarelli

Minh T N Nguyen

Ks Keshava Murthy

Craig Stewart

Laura Kaye Montemayor

Nageib Mohamed

Kaarina K Milnes

Kevin Wade Kells

Randa E El-Haj

This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A, Aand Aare independently selected from the group consisting of: H, X, OR, CN, CONRand C0R; Ris C-Calkyl; Ris H or C-Calkyl; Ris C-Calkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.

Processes for the preparation of 3-alkyl indoles

There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I) 

Methods of making lubiprostone and intermediates thereof

Provided for in the instant application are two additional forms of rifaximin, namely rifaximin polymorphic forms APO-III and APO-IV. Also provided are allegedly novel processes for preparing the previously disclosed rifaximin polymorphic forms APO-I and APO-II. Rifaximin is a non-aminoglycoside antibiotic that has previously been found to be useful for the treatment of traveller's diarrhea caused bybacteria, as well as in the treatment of irritable bowel syndrome, diverticular disease, hepatic encephalopathy, pyogenic skin infections and as an antibacterial prophylactic prior to colon surgery.

Polymorphic forms of rifaximin

A process is provided for preparing pharmaceutical grade atorvastatin hemicalcium salt comprising:  

Process for producing atorvastatin hemicalcium

A process for preparing torsemide or salts thereof comprising:

Process for the preparation of torsemide and related intermediates

Growing community of inventors

Brantford, Canada

Sammy Chris Duncan