Lupin, Inc.

Samiron Phukan

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Bhavesh Dave

Rakesh Kumar Banerjee

Abhijit Datta Khoje

Rajkumar Hangarge

Jitendra Sambhaji Jadhav

Milind Dattatraya Sindkhedkar

Manojkumar Ramprasad Shukla

Prathap Sreedharan Nair

Navnath Bajirao Walke

Sachin Sethi

Sanjay Pralhad Kurhade

Nilesh Raghunath Khedkar

Balasaheb Arjun Gore

Pradeep Rangrao Patil

Dagadu Dube

Vikas Sitaram Tambe

Pradip Balu Wagh

Sudhakar Maruti Balgude

Ganesh Kakade

Venkata P Palle

Vipul Pachpute

Sachin Mahangare

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, Rto R, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Substituted tricyclic compounds

The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below: 

Heterocyclyl compounds as MEK inhibitors

The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them. 

Heterocyclyl compounds

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Pune, India

Samiron Phukan