Leland Stanford Junior University

Samira Guccione

Mark David Bednarski

King Chuen Li

Sanjiv Sam Gambhir

Aloma L D'Souza

Gary M Glazer

Christopher C Caires

Embodiments of the present disclosure provide for methods of studying (e.g., detecting, localizing, and/or quantifying) biomarker(s) and the like.

Methods of studying a biomarker, and methods of detecting a biomarker

The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20&#xb0; C. to about 35&#xb0; C., thereby obtaining a fluorinated organic product.

Methods for silver-promoted fluorination of organic molecules

The in vivo delivery of nucleic acids is targeted by delivery of the nucleic acid in a complex with cross-linked nanoparticles; where the nanoparticles comprise cross-linked neutral amphipathic molecules, cationic amphipathic molecules and targeting amphipathic molecules. Optionally the cationic and targeting amphipathic molecules are also cross-linked. A targeting moiety present on the targeting amphipathic molecule provides for selective delivery of the complex to a predetermined target site, e.g. blood vessels, endothelial cells, tumor cells, liver cells, and the like.

Targeted cross-linked nanoparticles and their use in vivo gene delivery

Use of targeted cross-linked nanoparticles for in vivo gene delivery

Growing community of inventors

Hillsborough, CA, United States of America

Samira Guccione