Sanofi-aventis

Synthelabo

Sanofi-synthelabo

Sanofi

Samir Jegham

Pierre Casellas

Alistair Lochead

Bernard Bourrie

Alain Nedelec

Yvette Muneaux

Fr&eacute;d&eacute;ric Galli

Philippe Burnier

Frederic Puech

Pierre Perreaut

Daniel Floutard

Pierre Fraisse

Camille-Georges Wermuth

Thomas A Purcell

Jean-Marie Derocq

Paola Ciapetti

Luc Even

Thierry Gallet

Jean Jeunesse

Axelle Samson

Danielle Berthon

Bernard Labeeuw

Frederic Galli

Claude Muneaux

Gerard Defosse

Johannes Schoemaker

Jean Jacques Koenig

Pierre Carayon

Jean-Marie Deroco

Odile Leclerc

Axelle Solignac

Patrick Andre Lardenois

Jean-Jacques Koenig

Lydia Zard

Frédéric Galli

Stephane Hourcade

Jean-Robert Labrosse

Florence Durand

Itzchak Angel

G Erard Defosse

Yves Guminski

Laurence De Cruz

The disclosure relates to compounds of formula (I): wherein R, R, R, R, are Rare as defined in the disclosure; their preparation method, compositions containing the same and therapeutic use thereof.

6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof

The present disclosure relates to pyridoindolone derivatives of general formula (I): to processes for preparing the same and to their use in therapeutics.

Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics

Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar, Arand Ras defined herein, which are useful for treating cell proliferative conditions, and to the preparation thereof, and to the therapeutic application of the same.

Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof

The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.

Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof

The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I): wherein R, R, R, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).

2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof

The present disclosure relates to pyridoindolone derivatives of general formula (I): in which Rto Rare as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.

Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics

Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R, R, R, R, and R, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.

6-substituted pyridoindolone derivatives, production and therapeutic use thereof

The invention relates to 2-acylamino-4-phenylthiazole derivatives of general formula (I): pharmaceutically acceptable acid-addition salts thereof, hydrates or solvates of such derivatives or such pharmaceutically acceptable acid addition salts, intermediates thereto, processes for the preparation thereof, and therapeutic application thereof.

2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof

The disclosure concerns 2-carbamide-4-phenylthiazole derivatives of general formula (I). The disclosure also concerns pharmaceutical compositions containing a compound of general formula (I) and to processes for preparing and methods of using compounds of general formula (I). 

2-Carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof

The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below: in which R, R, R, Y, m, n, and p are as defined in the disclosure; as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic use thereof.

2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof

The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.

The present invention relates to pyridoindolone derivatives substituted in the 3-position by a heterocyclic group of general formula (I): in which: Preparation process and application in therapeutics.

Growing community of inventors

Montferrier-sur-Lez, France

Samir Jegham