California Institute of Technology

Indi Molecular, Inc.

Samir Das

James R Heath

Arundhati Nag

Ryan K Henning

Paul Edward Kearney

Heather Dawn Agnew

Blake Farrow

Rosemary Dyane Rohde

Bert Tsunyin Lai

Suresh Mark Pitram

Steven Wesley Millward

Aiko Umeda

Kaycie Deyle

Ashwin N Ram

David Bunck

Jingxin Liang

Joseph O Varghese

Paul Kearney

The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

Phosphorylated Akt-specific capture agents, compositions, and methods of using and making

Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, L, L, G, M, YYand SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.

Cyclic peptides as protein targeting agents

Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

Cyclic peptide binder against oncogenic K-Ras

The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

IL-17F-specific capture agents, compositions, and methods of using and making

The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.

Akt-specific capture agents, compositions, and methods of using and making

Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

Growing community of inventors

Pasadena, CA, United States of America

Samir Das