Bruker Biospin Ag

Ecole Polytechnique Federale De Lausanne

Ecole Polytechniqye Fédérale De Lausanne (edfl)

Ecole Polytechnique Féderale De Lausanne (epfl)

Sami Jannin

Geoffrey Bodenhausen

Joost Lohman

Aurélien Bornet

Frank Engelke

Paul Romeo Vasos

Riddhiman Sarkar

Arnaud Comment

Antonio Giuseppe Gianotti

Klaes Golman

Pascal Mieville

Roberto Melzi

Paul Vasos

A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high &#x3b3; nuclei with a short T, a polarizing agent with a broad EPR line, and low &#x3b3; nuclei with a long T. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B&#x2267;4.0 T, thus polarizing the high &#x3b3; nuclei by DNP, and the polarization is transferred from the high &#x3b3; nuclei to the low &#x3b3; nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low &#x3b3; nuclei from the target material. Nuclei with a long longitudinal relaxation time Tcan thereby be quickly hyperpolarized to a high polarization level.

MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation has the following steps: a) providing a solid sample (), containing long Tnuclei and short Tnuclei in the same molecules (); b) hyperpolarizing the short Tnuclei in the solid sample (); c) transforming the solid sample () into a liquid sample (); and d) transferring the polarization of the short Tnuclei to the long Tnuclei within the molecules in the liquid sample () by Cross Polarization. The method can provide samples with hyperpolarized long Tnuclei, in particularC orN, in a simple and efficient way.

Method for hyperpolarization transfer in the liquid state

A method for nuclear magnetic resonance (NMR) spectroscopy of a sample involves excitation of long lived coherences (LLC) between the singlet state Sand the central triplet state Tof nuclei of the sample by initiating irradiation of the sample with an rf-field with carrier frequency &#x3c9;; sustaining of the LLC by maintaining the rf-irradiation during an interval &#x3c4;; converting the LLC temporarily into observable magnetization by interrupting the rf-irradiation during an observation interval &#x3c4;; detecting NMR-signals during the observation interval &#x3c4;and reconversion of the observable magnetization back into LLC after the observation interval &#x3c4;. These steps are repeated n times, wherein n is a positive integer. The method allows ultra high-resolution spectra of long-lived coherences to be obtained.

Method for NMR spectroscopy with sustained induction decays of long-lived coherences

A method for sample preparation for magnetic resonance measurements using Hyperpolarization by Dissolution Dynamic Nuclear Polarization, involves preparation of frozen beads of a first kind containing paramagnetic substances in addition to the solute under investigation; insertion of the frozen beads into a polarizing magnet; creation of enhanced polarization of nuclei in a magnetic field; heating of the sample to room temperature; transfer of the sample to an MR magnet; and carrying out an MR measurement. In addition, frozen beads of a second kind containing a reducing agent are prepared and inserted into the polarization magnet together with the frozen beads of the first kind. By this method, longitudinal and transverse relaxation times in NMR are extended and free radicals in hyperpolarized solutions are eliminated.

Method for NMR spectroscopy or MRI measurements using dissolution dynamic nuclear polarization (DNP) with scavenging of free radicals

A method for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements, includes creation of enhanced polarization of nuclei of a first kind within a sample in a magnetic field at cryogenic temperatures and transfer of the polarized sample to room temperature. The enhanced polarization of nuclei of the first kind is thereby transformed into long-lived states (LLS) of nuclei of a second kind and these LLS are sustained. The LLS is at least partially converted into observable magnetization and an NMR or MRI measurement is carried out. The method allows one to extend the time needed between hyperpolarized magnetization and NMR detection.

Methods for nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) measurements using long-lived states

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Lausanne, Switzerland

Sami Jannin