Medtronic, Inc.

Sameh Sowelam

H Toby Markowitz

Yong Kyun Cho

Todd Jon Sheldon

Douglas A Hettrick

Mark K Erickson

Kenneth C Gardeski

Phillip C Falkner

Thomas J Mullen

Chad Giese

Pooja Mehta

Rajan Prakash

Raylene Pitschneider

Ioana Nicolaescu

Abed E Lawabni

Marina Jovanovic

A medical device monitors a level of fluid accumulation, e.g., pulmonary edema, and one or more respiratory parameters of the patient to detect worsening heart failure. The medical device may use intrathoracic impedance measurements to monitor both the fluid accumulation and the one or more respiratory parameters. Respiration rate and volume, also referred to as the tidal volume, are examples of respiratory parameters. The medical device examines the one or more respiratory parameters after determining that the fluid accumulation indicates worsening heart failure. In this manner, the medical device uses the one or more respiratory parameters to confirm a determination of worsening heart failure that was made based on the fluid accumulation.

Detecting worsening heart failure based on fluid accumulation with respiratory confirmatoin

Detecting worsening heart failure based on fluid accumulation with respiratory confirmation

The implantable medical device (IMD) system disclosed here utilizes one or more cardiac sensors that measure mechanical characteristics of the heart, such as left ventricular acceleration or right ventricular pressure. The raw sensor data is collected and processed by the IMD, which derives one or more mechanical event marker signals from features, traits, and characteristics of the sensor data waveforms. The mechanical event marker signals are wirelessly transmitted to an external monitor device for display.

Mechanical function marker channel for cardiac monitoring and therapy control

An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.

System and method to evaluate electrode position and spacing

A system and method for monitoring in a patient includes producing sensor signals representative of a physiologic parameter associated with respiration. A periodic breathing cycle is detected based on the sensor signals. An output is produced as a function of the cycle length.

System and method for monitoring periodic breathing associated with heart failure

Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.

Medical methods and systems incorporating wireless monitoring

The present invention relates to a device and method for monitoring for sleep disordered breathing or other types of disordered breathing such as Cheyne-Stokes breathing. More specifically, a device and method for detecting disordered breathing is provided that monitors a physiological parameter, which becomes cyclical due to apnea-hyperpnea (or arousal) alternation and provides the basis for the determination of a number of breathing disorder metrics.

Apparatus and method for monitoring for disordered breathing

Oxygen saturation data is monitored during a predefined window to obtain a measurement of circulation delay. The measured circulation delay is used as a basis for determining therapies, including overdrive pacing. In some embodiments, circulation delay is used to identify patients that will benefit from overdrive pacing as a therapy for sleep disordered breathing.

Implantable medical device with circulation delay measurement and therapy control

A system and automated method for assessing ventricular synchrony in ambulatory patients is provided including at least one mechanical sensor (e.g., accelerometer, tensiometric sensor, force transducer, and the like) operatively coupled to a first myocardial location in order to measure a wall motion signal of a first chamber, and a second mechanical sensor operatively coupled to a second myocardial location in order to measure a wall motion signal of a second chamber. The wall motion signals are processed in order to identify the time at which a fiducial (e.g., an inflection point, a threshold crossing, a maximum amplitude, etc.) occurs for each respective signal. The temporal separation between the fiducial points on each respective signal is measured as a metric of ventricular synchrony and can be optionally utilized to adjust pacing therapy timing to improve synchrony.

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Maple Grove, MN, United States of America

Sameh Sowelam