California Institute of Technology

Other

University of California

University of Southern California

Sameer Walavalkar

Axel Scherer

Andrew Peter Homyk

Michael David Henry

Thomas Anthony Tombrello, Jr

Aditya Rajagopal

Chieh-feng Chang

Scott E Fraser

William M Jones

Erika F Garcia

Thai Viet Truong

Danil M Lukin

Brandon C Marin

Mark D Goldberg

Andrea R Tao

Methods for fabricating flexible substrate nanostructured devices are disclosed. The nanostructures comprise nano-pillars and metallic bulbs or nano-apertures. The nanostructures can be functionalized to detect biological entities. The flexible substrates can be rolled into cylindrical tubes for detection of fluidic samples.

Fabrication and self-aligned local functionalization of nanocups and various plasmonic nanostructures on flexible substrates for implantable and sensing applications

Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars extending through the metallic layer. A plurality of regions of concentrated light can be supported in proximity to the ends of the plurality of dielectric pillars when a surface of the metallic layer is illuminated. Concentrated light within one or more of these regions can interact with an analyte molecule, allowing for detection of the analyte.

Optical sensor for analyte detection

Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the other occurs. The gap is dimensioned such that only a low voltage is required to induce field emission. As a result, the emitted electrons energy that is below the ionization potential of the gas or gasses that reside within the gap. In some embodiments, the gap is small enough that the distance between the electrodes is shorter than the mean-free path of electrons in air at atmospheric pressure. As a result, the field-emission devices do not require a vacuum environment for operation.

Nanoscale field-emission device and method of fabrication

Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

Multiplexed surface enhanced Raman sensors for early disease detection and in-situ bacterial monitoring

Plasmonics nanostructures for multiplexing implantable sensors

Reflowed gold nanostructures for surface enhanced raman spectroscopy

Surface enhanced Raman spectroscopy detection of gases, particles and liquids through nanopillar structures

Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Devices and methods for sequencing nucleic acids

Novel methods to fabricate biological sensors and electronics are disclosed. A silicon-on-insulator wafer can be employed by etching a pattern of holes in the silicon layer, then a pattern of cavities in the insulating layer, and then sealing the top of the cavities. Further, n or p doped regions and metallic regions can be defined in the processed wafer, thereby enabling integration of biological sensing and electronic capabilities in the same wafer.

Silicon-on-insulator microchannels for biological sensors

Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Methods for fabricating self-aligning semiconductor hetereostructures using nanowires

Growing community of inventors

Studio City, CA, United States of America

Sameer Walavalkar