Iowa State University Research Foundation Inc

Sameer Urgaonkar

John G Verkade

JuHua Xu

A method is provided to couple an aryl halide to an alkyne comprising reacting a compound of the formula ArX, wherein Ar is a substituted or unsubstituted aryl group and X is I or Br, with a compound of the formula HC&#x2261;C&#x2014;Rwherein Ris a substituted or unsubstituted organic group, in the presence of an effective amount of a phosphine-free, oxime-free palladium catalyst; (C-C)alkyl N(OAc) or an alkali metal carbonate, to yield a compound of the formula Ar&#x2014;C&#x2261;C&#x2014;R, wherein the reaction is carried out in the absence of an organic amine or copper(I).

Palladium-catalyzed coupling of aryl halides with alkynes

Methods and compounds are provided for the formation of carbon-nitrogen or carbon-carbon bonds comprising reacting an amine or an aryl boronic acid with an aryl halide in the presence of a palladium catalyst, a base, and a compound of formula II: 

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Cambridge, MA, United States of America

Sameer Urgaonkar