Astrazeneca Ab

Dizal (jiangsu) Pharmaceutical Co., Ltd.

Astazeneca Ab

Dizal Pharmaceutical Co., Limited

Sameer Pralhad Kawatkar

Jason Grant Kettle

Qibin Su

Maurice Raymond Verschoyle Finlay

Iain Simpson

Melissa Vasbinder

Claudio Edmundo Chuaqui

Scott Nathan Mlynarski

Tyler Grebe

Neil Patrick Grimster

James Francis McCabe

Dedong Wu

Steve Cook

Magnus K Nilsson

Jon James Winter-Holt

Richard Donald Woessner

Linette Ruston

Jianyan Wang

Annika Birgitta Margareta Astrand

Anna Ingrid Kristina Berggren

Johan R Johansson

Karl Magnus Nilsson

Matti Juhani Lepistö

Matti Juhani Lepisto

Wenzhan Yang

Annika Astrand

James Mccabe

Annika Birgitta Margareta Åstrand

Tudor Grecu

Melissa Marie Vasbinder

Annika Birgitta Margareta ÅStrand

Linette Lys Ruston

Disclosed are compounds of formula (Ib) or (Vc), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ib) or (Vc) and methods of using the same for treating cancer, respiratory inflammatory disease, and inhibiting arginase; wherein Ris —H or —C(O)CH(R)NHR; and Ris selected from —H, —(C-C) alkyl and CHOR; Ris —H; or alternatively, Rand R, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and Ris H or —CH.

Arginase inhibitors and methods of use thereof

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein

Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R-Rhave any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

JAK1 selective inhibitors

Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein

Compounds and methods for inhibiting JAK

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Wilmington, DE, United States of America

Sameer Pralhad Kawatkar