The Brigham and Women's Hospital, Inc.

The Broad Institute, Inc.

Sameek Singh

Amit Choudhary

Vika Anokhina

Prashant Singh

Ashley Modell

Praveen Tiwari

Uttam Dhawa

Veronika Shoba

Santosh Chaudhary

The present disclosure relates to chimeric small molecules, which find utility as modifiers of target substrates according to the formula A-L-E-B or A-L-E-L-B, wherein A is a kinase binding moiety; B is a target binding moiety; Land Lare each a linker; and E is an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to targets that are not the natural substrate of the kinase; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure.

Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof

Growing community of inventors

Cambridge, MA, United States of America

Sameek Singh