University of Florida Research Foundation, Incorporated

Samantha Lauren Marshall

Wallace Gregory Sawyer

Derek L Hood

Angela Athena Pitenis

Eric O McGhee

Alexander McGhee

Kylie E Van Meter

Juan Manuel Urueña

Michael Dougherty

Christian Jobin

Padraic P Levings

Jack E Famiglietti

Ryan A Smolchek

Kylie Van Meter

Juan Manuel URUEÑA

Disclosed herein is a bioreactor system that allows active perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprise a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. In some embodiments, application of negative gage pressure to the medium collection chamber or positive pressure to the liquid medium reservoir draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.

Perfusion enabled bioreactors

Growing community of inventors

New York, NY, United States of America

Samantha Lauren Marshall