Allergan, Inc.

Allergan Pharmaceuticals

Allegan, Inc.

Sam W Lam

Stanley William Huth

Paul S Ripley

Vicky Hoang

Abraham M Espiritu

J Abraham Espiritu

Anthony J Dziabo

Hampar Karageozian

Bob Lam

Richard M Kiral

Six panel hybrid fitted cap

Five-panel fitted hat

A method for simultaneously cleaning and disinfecting contact lenses includes forming a disinfection solution containing an ophthalmically safe amount of a disinfecting agent, such as polyhexamethylene biguanide, and providing an effective amount of a proteolytic enzyme, such as subtilisin A. The disinfecting agent and proteolytic enzyme are selected such that in the working solution, the disinfection efficacy of the disinfecting agent is at least maintained. Preferably, after cleaning and disinfection, the lens can be rinsed with the disinfection solution, whereby the lens may then be directly inserted in the eye of the contact lens user without further rinsing.

Non-oxidative method and composition for simultaneously cleaning and

Compositions and methods to clean contact lenses are disclosed. In one embodiment, the present composition comprises at least at least one enzyme capable of removing debris from a contact lens and at least one disinfectant destroying component capable of destroying a contact lens disinfectant which is incompatible with the at least one enzyme. The composition is structured so that the at least one enzyme is released in a liquid medium containing the contact lens disinfectant at substantially the same time or after the at least one disinfectant destroying component is released in the liquid medium, thereby allowing the at least one enzyme to remove debris from a contact lens in the liquid medium.

Compositions and methods to clean contact lenses

Methods for disinfecting a lens is disclosed. The methods comprise contacting a lens to be disinfected in a liquid medium with at least one chlorine dioxide precursor in the presence of at least one activator component selected from organic acid anhydrides, oxygen-releasing components and mixtures thereof to effect formation of chlorine dioxide from the chlorine dioxide precursor, thereby disinfecting the lens. Compositions useful in the above-noted methods are also disclosed.

Method and activator compositions to disinfect lenses

A method for removing yellow contact lens discoloration involves immersing yellow colored contact lenses in a solution including a proteolytic enzyme and a reducing agent and then heating the solution for a time and at a temperature sufficient to remove substantially all yellow contact lens discoloration. The method also functions to simultaneously clean, disinfect and remove yellow discoloration from a contact lens. The lens is immersed in an aqueous solution including an effective amount of a thiol and an enzyme, and the solution is heated above ambient temperature for a time and at a temperature sufficient to remove substantially all yellow contact lens discoloration and contact lens protein accretions and to disinfect the lens. Preferably the solution is heated to a maximum temperature in a range of approximately 80.degree. C. to approximately 90.degree. C.

Method for simultaneously cleaning, decolorizing and thermally

A one step method for cleaning and disinfecting contact lenses is accomplished by immersing the lenses in a solution containing peroxide and a peroxide-active enzyme.

Method for the simultaneous cleaning and disinfecting of contact lenses

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Laguna Niguel, CA, United States of America

Sam W Lam