Purdue Pharma L.p.

Euro-Celtique S.a.

Sam Victory

Donald Kyle

R Richard Goehring

Qun Sun

Zhengming Chen

John Whitehead

Laykea Tafesse

Parviz Gharagozloo

Gary Lee

A compound of formula: wherein Ar, A, R, x, and m are as disclosed herein and Aris a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a 'Benzoazolylpiperazine Compound'), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

Therapeutic agents useful for treating pain

A compound of the formula (I), (II), (III) or (IV) 

Nociceptin analogs

The invention relates to benzothiadiazole compounds of formula (I):  and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R, R, A, B, C, W, Z and n are defined as set forth in the specification. The compounds of the invention have affinity for the nociceptin receptor. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to modulation of the nociceptin receptor. Compounds of the present invention are especially useful for treating pain.

Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount of a Triazaspiro Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a Triazaspiro Compound are disclosed.

Triazaspiro compounds useful for treating or preventing pain

This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R, R, Rand Rare defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Aryl substituted pyrimidines and the use thereof

Disclosed are compounds of the formula (I)wherein R, RRRR, Rand N are as disclosed herein. The compounds are useful for the treatment of chronic and acute pain.

Tertiary amino compounds having opioid receptor affinity

Disclosed are compounds of the formula (I):wherein A, B, C, M-M, R, R, Rand n are as described herein.

Benzimidazolone compounds

A compound of the formula (I), (II), (III) or (IV)

Growing community of inventors

Newtown, PA, United States of America

Sam Victory