Universiteit Gent

Microbial Resource Management Health Nv Mrm Health

Bioactor Bv

Microbial Research Management Health Nv

Universllell Gent

Microbial Resource Management Heal

Prodigest Bvba

Bioactor Bvba

Mrm Health N.v.

Microbial Resource Management Health Nv

Sam Possemiers

Massimo Marzorati

Tom Van De Wiele

Selin Bolca

Ilse Scheirlinck

Davide Gottardi

Pieter Van Den Abeele

Pieter Van Den Abbeele

Willy Verstraete

Antonie Johannes Van Der Saag

Yala Stevens

Barbara Vanhoecke

Denis De Keukeleire

Peter Frank Ekhart

Hans Van Der Saag

Audrey Martine Neyrinck

Nathalie Maria Nelly Delzenne

Patrice D Cani

Cindy Duysburgh

Louis-Philippe Mascart

Tim Windels

Iris Pinheiro

Bouke Salden

Arne Heyerick

Nathalle Maria Delzenne

Joana Lopes

Suchita Panda

Cani Patrice D D

The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.

Use of microbial communities for human and animal health

Gastrointestinal tract simulation system and compartment therefor. The compartment comprising a vessel having an open top surrounded by a peripheral edge portion and an air-tight lid system configured to be placed onto the peripheral edge portion. The lid system comprises a body with a plurality of passageways extending through the body and providing access to the interior of the vessel, the plurality of passageways comprising passageways for fluid transfer tubes and passageways for mounting at least one sensor component. The lid system is provided with releasable sealing elements for sealing the plurality of passageways and at least one pressing element which is common to at least a number of the sealing elements and configured for applying pressure to each of the respective sealing elements to effect the sealing of the respective passageways.

Gastrointestinal tract simulation system, compartments therefor, and method

The present invention relates to the use of carotenoids, in particular a microbial carotenoid compound of formula I, such as methyl-glycosyl-apo-8'-lycopenoate or glycosyl-apo-8&#x2032;-lycopene, for restoring and/or maintaining a health-beneficial gut microbial composition in a subject. The invention further provides the use of said compound in the treatment of disorders associated with a disturbed intestinal barrier integrity, such as for example irritable bowel syndrome. Further, a compound or composition comprising a microbial carotenoid compound is disclosed for use in the prevention and/or treatment of disorders associated with disturbed intestinal barrier integrity.

Microbial carotenoids affecting gut microbial composition

The present invention provides the use of a compound of formula I, and compositions comprising such a compound, for improving power output and/or oxygen efficiency in a subject.

Compounds and compositions for improving power output and oxygen efficiency

The present invention relates to compounds of formula (I), such as hesperitin-7-rutinoside 2S, for use in the treatment of visceral hypersensitivity. Compounds and compositions of the invention are particularly useful in the treatment of visceral hypersensitivity in a subject having irritable bowel syndrome or age-associated low grade systemic inflammation of the gut, but lacking spasmodic intestinal contractions.

Flavanones for use in treating visceral hypersensitivity

The present disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria are grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.

The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.

Enzymatic demethylation of flavonoids

A method is provided for co-culturing viable cells and microorganisms for at least 48 hours in which an adhesion module is provided including a basal compartment and a luminal compartment separated by a semi-permeable membrane, and a continuous or semi-continuous flow of fresh medium is applied to the basal compartment.

Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interaction

The present invention is directed to a particular arabinoxylan ('AX') preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such asor

Arabinoxylans for modulating the barrier function of the intestinal surface

Growing community of inventors

Zwijnaarde, Belgium

Sam Possemiers