Selecta Biosciences, Inc.

Ares Trading S.a.

Peptimmune, Inc.

Sam Baldwin

Charles M Zepp

Yun Gao

Grayson B Lipford

Lloyd Johnston

Fen-ni Fu

Mark J Keegan

Jianxin Zhang

Dustan Bonnin

Eric Zanelli

James Rasmussen

Bei Yu

Keith Johnson

This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

Immunomodulatory agent-polymeric compounds

The invention relates to novel methods and kits for treating or preventing disease through the administration of random copolymers comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K). The invention also relates to the treatment of autoimmune diseases, such as multiple sclerosis, and to the administration of random copolymers in treatment regimen comprising formulations that are administered at intervals greater than 24 hours, or to sustained release formulations which administer the copolymer over a period greater than 24 hours. The invention further relates to methods for conducting a pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the formulations or dosing regimens of random copolymer described herein.

Methods of treating disease with random copolymers

Growing community of inventors

Westford, MA, United States of America

Sam Baldwin