Bristol-myers Squibb Compnay

Bristol-myers Company

Salvatore Forenza

Kin S Lam

James A Matson

Jacqueline M Mattei

Daniel R Schroeder

Leonard A McDonald

Koji Tomita

James A Bush

Sandra J Hofstead

Kin Sing Lam

James Andrew Matson

Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.

Rebeccamycin analogs by tryptophan analogs feeding

A new antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.

Antitumor antibiotic BMY-41219

An antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.

Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative having advantageous antineoplastic properties.

Rebeccamycin

Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues.

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Cheshire, CT, United States of America

Salvatore Forenza