Nogra Pharma Limited

Salvatore Demartis

Francesca Viti

Salvatore Bellinvia

Marie McNulty

The disclosure provides a process for the preparation of 3-(4'-annitophenyl)-2-metlioxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

Process of making 3-(4'-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof

The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-γ in a subject.

Aryl receptor modulators and methods of making and using the same

The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

Process of making 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof

The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-&#x3b3; in a subject.

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Milan, Italy

Salvatore Demartis