Regenerative Research Foundation

Albany Medical College

Sally Temple

David Butler

Jeffrey Stern

Enrique L Salero-Coca

Anne Messer

Susan K Goderie

Qin Shen

Disclosed herein are multifunctional polypeptides comprising a first domain comprising an anti-tau antigen binding domain and a second domain comprising a proteasome-targeting PEST motif, and methods for using these polypeptides in treatment of tauopathies.

Bi-functional anti-tau polypeptides and use thereof

The present invention relates to a retinal pigment epithelial stem cell isolated from a posterior region of the retinal pigment epithelium of an adult mammal. The invention also relates to a method of inducing differentiation of retinal epithelial stem and progenitor cells in vitro, wherein the cells of the invention are highly plastic, multipotential stem cells. The invention also includes methods for the treatment of retinal diseases and vision loss involving the transplantation of retinal pigment epithelial stem cells or cells differentiated from retinal pigment epithelial stem cells to the retina of a patient in need of treatment.

Methods of treating a retinal disease by retinal pigment epithelial stem cells

Retinal pigment epithelial stem cells

The present invention provides a mechanism for obtaining an almost unlimited source of stem cells. A method for the expansion of a population of stem cells that retain their developmental capacity comprises co-culture of a stem cell population with a trophic support, for example, endothelial cells or conditioned medium derived from endothelial cell culture. The method also provides a method for enhancing neurogenesis when neural stem cells are co-cultured with the endothelial cell-derived trophic support to retain their neurogenic potential.

Method for stimulating self-renewal of neural stem cells and enhancing neurogenesis

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Slingerlands, NY, United States of America

Sally Temple