Pfizer Corporation

Sally Gut Ruggeri

Joel Michael Hawkins

Anthony D Piscopio

Robert Wayne Dugger

Jeffrey W Raggon

Michael J Castaldi

Sarah E Kelly

Frank J Urban

Stephane Caron

Jennifer L Rutherford

Stephanie Caron

Teresa M Makowski

Lawrence S Melvin, Jr

Yuhpyng Liang Chen

Kevin Koch

Lawrence Alan Reiter

This invention relates to methods and intermediates useful for the synthesis of pyrrolo[2,3-d]pyrimidine compounds. Specifically novel synthetic methods and intermediates for the synthesis of 3-{(3R,4R)-4-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino}-piperidin-1-yl)-3-oxo-propionitrile and its corresponding citrate salt are disclosed.

Pyrrolo[2,3-d]pyrimidine derivatives: their intermediates and synthesis

Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis

Processes and intermediates for preparing substituted chromanol derivatives

This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R,is (C,-C,)alkyl; R,is methyl or ethyl; and R,, R,and R,are selected, independently, from (C,-C,)alkyl and (C,-C,)alkoxy; or a pharmaceutically acceptable salt thereof; comprising reacting a compound of formula (II), wherein R,and R,are defined as above, with a compound of formula (III), wherein R,, R,and R,are defined as above, in the presence of a base that is capable of deprotonating the compound of formula (III), optionally in the presence of an organometallic halide or oxide and a suitable solvent, and then optionally converting the resulting compound of formula (I) into a pharmaceutically acceptable salt of such compound.

Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines

The invention relates to processes for preparing a compound of the formula

Processes for preparing substituted chromanol derivatives

Benzopyran and related LTB.sub.4 antagonists

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Waterford, CT, United States of America

Sally Gut Ruggeri