Ethicon, Gmbh

Rutgers, the State University of New Jersey

Salim A Ghodbane

Sridevi N Dhanaraj

Ashley DeAnglis

Michael J Trezza, Ii

Simon Cohn

Jianxin Guo

Charles Gatt, Jr

Kevin Shaun Weadock

Guanghui Zhang

Nir I Nativ

Michael G Dunn

Sai Veruva

Thomas C Weindl

Michael Dunn

Ii Michael J Trezza

The present invention provides a kit for preparing a composition for sealing a lung tract, comprising: (a) a first component comprising: (i) a fibrinogen solution, and (ii) prewet gelatin particles in an aqueous solution; and (b) a second component comprising: (i) a thrombin solution, and (ii) a dry gelatin powder; wherein the first and second components are stored separately and configured for mixing together to form a composition that is flowable and cross-linkable. The composition may be used to seal tissue tracts such as lung tissue tracts.

Kit for composition for tissue tract sealing

A method for fabricating a resorbable scaffold for regeneration of meniscal tissue is disclosed. The method includes fabricating a polymer filament network using 3D printing in accordance with a digital model of the polymer filament network, such that the polymer filament network will include a first plurality of layers comprising the circumferentially-oriented filaments alternating with a second plurality of layers comprising the radially-oriented filaments, the polymer filament network having a three-dimensional shape and geometry between a first layer and a second layer which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

Polymer filament reinforced scaffold for partial meniscus regeneration

A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

Systems, devices and methods for reconstituting therapeutic powders, mixing precursor solutions, and expressing sealants for controlling bleeding and sealing fluid and air leaks

A spray tip for dispensing fluids that react together includes a first lumen for a first fluid, a second lumen for a second fluid, and a dispensing cap located at distal ends of the respective first and second lumens and defining a distal end of the spray tip. The dispensing cap includes a distal end wall defining a closed end of the dispensing cap, a first spray opening formed in the distal end wall that is in fluid communication with the first lumen, a second spray opening formed in the distal end wall that is in fluid communication with the second lumen, and an external dividing wall that projects distally from the distal end wall of the dispensing cap and that extends between the first and second spray opening for forming a barrier between the first and second spray openings.

Dispensing systems and devices having anti-clogging spray tips for dispensing two or more fluids that react together

Provided herein are compositions, systems and surgical methods for treating expandable soft tissue utilizing a reactive liquid hydrogel sealant mixture including a cross-linkable electrophilic compound, a nucleophilic compound, and an amphiphilic poly(alkyl)ene glycol block polymer in an amount of 20% (w/v) or less of the sealant composition. The composition can optionally include a viscosifier, in an amount of 0.1% to 1.0% (w/v) of the sealant composition.

Highly elastic medical sealants for flexible soft tissue

A spray device includes side-by-side spray tips that are spaced from one another at a distal end of the spray device. A first spray tip has a first fluid pathway defining a first flow area. The first fluid pathway has a first swirl chamber having an outer perimeter and flutes having inner ends that direct a first fluid into the outer perimeter of the first swirl chamber for rotating the first fluid in a circular pattern. A second spray tip has a second fluid pathway that defines a second flow area that is larger than the first flow area. The second fluid pathway has a second swirl chamber having an outer perimeter and flutes having inner ends that direct a second fluid into the outer perimeter of the second swirl chamber for rotating the second fluid in a circular pattern.

Spray devices including side-by-side spray tips having fluid pathways with swirl chambers for dispensing two fluids that chemically react together

A method of sealing a resected surface of an organ includes applying a synthetic matrix to a resected surface of an organ, and applying an adhesive on the synthetic matrix so that the adhesive penetrates through interstices of the synthetic matrix for contacting an interface between the synthetic matrix and the resected surface of the organ. The method includes curing the adhesive for bonding the synthetic matrix to the resected surface of the organ. The synthetic matrix is a non-woven mesh made of polyglactin 910 or any other synthetic or non-synthetic fabric having a similar porosity or density. The adhesive is a biosynthetic or a synthetic adhesive. After penetrating through the pores of the synthetic matrix and curing, the cured biosynthetic or synthetic adhesive mechanically interlocks with the synthetic matrix for adhering the synthetic matrix to the tissue for creating a sealing barrier.

Two component sealing systems including synthetic matrices and biosynthetic adhesives for sealing resected surfaces of organs to control bleeding, fluid leaks and air leaks

A method and kit for stopping cerebrospinal fluid (CSF) leaks, comprising penetrating and passing through a dural tissue an applicator to access an interior dural space, injecting from the applicator a fibrinogen-containing solution into said dural space, applying a sealing member containing a fibrinogen polymerizing agent onto an exterior surface of the dural tissue, and forming a polymerized fibrinogen or polymerized fibrin clot by contacting the injected fibrinogen-containing solution and the fibrinogen polymerizing agent.

Method of stopping CSF leaks and apparatus therefor

A spray device includes a first spray tip having a first fluid pathway defining a first flow area, and a second spray tip includes a second fluid pathway that defines a second flow area that is larger than the first flow area of the first spray tip. The first and second spray tips are side-by-side and spaced from one another at a distal end of the spray device. When a first fluid having a volumetric flow rate is introduced into the first spray tip and a second fluid having the same volumetric flow rate is introduced into the second spray tip, the first fluid will flow through the first fluid pathway at a greater velocity than the second fluid will flow through the second fluid pathway.

Spray devices having side-by-side spray tips for dispensing two fluids that chemically react together

A resorbable scaffold for partial meniscus regeneration. The resorbable scaffold includes a polymer filament network and a matrix in the polymer filament network. The polymer filament network includes alternating layers of circumferentially-oriented filaments and radially-oriented filaments, and has a three-dimensional shape and geometry which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

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Piscataway, NJ, United States of America

Salim A Ghodbane