University of Iowa Research Foundation

Actibiomotion, LLC

Salam F Rahmatalla

Andrew A Pieper

Thomas Schnell

Anil K Chauhan

Charles W Harris, Jr

Varun Chalasani

Eric C Frick

Enrique C Leira

The disclosed apparatus, systems and methods relate to devices, systems and methods for improving thrombolysis via synergetic application of thrombolytics with physical factors, such as in acute ischemic stroke patients. Vibration in the low (0.5-120 Hz) frequency range is synergistic with tissue plasminogen activators (rtPA), significantly improving the effectiveness of thrombolysis without impairing blood brain barrier permeability. Administration of low frequency vibration combined with rtPA improve acute ischemic stroke outcomes.

Replication or mitigation of low frequency vibration and other physical factors to enhance the effect of thrombolysis on patients with ischemic stroke

The invention includes systems having a cover attached to a frame, and a transmission unit with a rotational device connected to or part of the frame. The cover is mechanically connected to the at least one rotational device. A vibration dampening unit mechanically connected to the transmission unit such that translational movement (e.g. vertical movements) of the cover causes rotational movement of the rotational device. The rotational movement is, in turn, transmitted to the vibration dampening unit via the transmission unit. Preferably, the vibration dampening unit is a passive unit and also a resistance force modulated vibration dampening unit. The invention also includes methods for dampening vibrations on a load which includes converting translational movement of a load to rotational movement in a transmission unit, the transmission magnifies the displacement and speed of the rotational movement, and then transmitting the rotational movement to a vibration dampening unit, which dissipated the vibrational energy.

Vibration dampening system

Growing community of inventors

Iowa City, IA, United States of America

Salam F Rahmatalla