Kureha Kagaku Kogyo Kabushiki Kaisha

Kureha Chemical Industry Company, Limited

Sakuo Noda

Hitoshi Takita

Yutaka Mukaida

Hidetoshi Kobayashi

Fumihiko Kimura

Toyohiko Nitta

Kazuyoshi Inada

Mari Toji

Kiyonori Umekawa

Kohju Watanabe

Kobayashi, Hidetoshi

Disclosed herein are a derivative of dihydroxybenzamide represented by the formula(I): ##STR1## wherein (1) R.sup.1 represents a hydrogen atom or a lower alkyl group and R.sup.2 represents a straight chain-alkyl group of 4 to 12 carbon atoms, a branched chain-alkyl group of 4 to 12 carbon atoms, a cyclo-alkyl group of 4 to 12 carbon atoms, ##STR2## wherein n is an integer of 1 to 6, or a pyridyl group which is substituted or unsubstituted, or (2) R.sup.1 and R.sup.2 are cyclized to make a heterocycle containing amino group represented by the formula ##STR3## wherein X represents a nitrogen atom or a methine and Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a phenyl group, and a pharmaceutical composition containing the same.

Derivative of dihydroxybenzamide and a pharmaceutical composition thereof

Novel saccharide derivatives of protocatechualdehyde represented by the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a benzoyl group, and R.sup.2 represents an alkyl group. The method for preparing thereof and the use of the compound as antiinflammatory agents.

Saccharide derivatives of protocatechualdehyde

Disclosed herein are dialkanoyloxybenzylidene dialkanoate represented by the formula ##STR1## wherein X.sup.1 and X.sup.2 represent respectively alkanoyloxy group and a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of inflammatory disease of the dialkanoyloxybenzylidene dialkanoate as an active ingredient thereof.

Dialkanoyloxybenzylidene dialkanoate

Disclosed herein are dialkanoyloxybenzylidene dialkanoate represented by the formula, ##STR1## wherein X.sup.1 and X.sup.2 represent respectively alkanoyloxy group and a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of inflammatory disease of the dialkanoyloxybenzylidene dialkanoate as an active ingredient thereof.

Derivative of dihydroxybenzamide and a pharmaceutical composition having

Disclosed herein are a pharmaceutical composition for treating nephritis, comprising at least one compound selected from the group consisting of the derivatives of N-(dihdyroxybenzylidene)amino acid, represented by the formula (I): ##STR1## wherein R represents an alkylene group having one to five carbon atoms, a phenylene group or ##STR2## the pharmaceutically acceptable salts and esters thereof, and a pharmaceutically acceptable carrier therefor, and the method for treating nephritis.

Pharmaceutical composition for treating nephritis and method for

A novel compound of 4-[N-(hydroxybenzyl)aminomethyl]-cyclohexane-1-carboxylic acid represented by the general formula (I): ##STR1## wherein n is an integer of 1 to 3, or a salt or an ester thereof which has specific pharmacological activities, a method for preparing the derivative and a pharmacological composition in dosage unit form comprising the derivative as an active ingredient are disclosed herein.

4-[N-(Hydroxybenzyl)aminomethyl]cyclohexane-1-carboxylic acid

A novel derivative of dihydroxybenzoic acid represented by the formula (I) ##STR1## wherein R represents ##STR2## or a salt or an ester thereof which has specific pharmacological activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Derivatives of dihydroxybenzoic acid and pharmaceutical composition

A novel compound of 4-[N-(3',4'-methylenedioxybenzylidene) aminomethyl]cyclohexane-1-carboxylic acid or a pharmaceutically acceptable salt or an C.sub.1 -C.sub.4 alkyl ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

4-(N-(3',4'-Methylenedioxybenzylidene)-aminomethyl)cyclohex

A novel compound of 4-[N-(3',4'-dihydroxybenzylidene) aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Derivative of 4-(N-(3,4-dihydroxybenzylidene) aminomethyl

A novel compound of 4-[N-(substituted-benzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.

Growing community of inventors

Tokyo, Japan

Sakuo Noda