Koite Health Oy

Sakari Nikinmaa

Juha T Rantala

Tommi Pätilä

Katja Ivanitskiy

Mikko Heikkinen

Jukka Kärkimaa

Jarmo Sääski

Method of treating biological surfaces with electromagnetic radiation in the form of light of two different energy levels, a first light with photons having a majority energy in the range from 3.5 eV to 2.8 eV and a second light with photons having a majority energy in the range from 1.24 eV to 2.48 eV. The photons of the first light and the second light are simultaneously directed against the biological surface. The invention also contemplates the use of sensitizers in topical treatments of infections using the method. The treatment will achieve good tissue penetration. It makes it possible to give antibacterial treatment to different areas of pathogen at the same time as two or more different energy photons can target molecules in different areas.

Method of treatment of biological surfaces

Antibiotic for use in a method comprising systemically administering a photosensitive antibiotic to a subject having a microbial infection in a target tissue to provide a blood plasma concentration of the antibiotic in the subject; allowing the plasma or tissue concentration of the antibiotic increase to a predetermined level; and subjecting the target tissue to photodynamic therapy in order to increase the antimicrobial action of the antibiotic in the target tissue. With light activation the efficacy of the photosensitizer antibiotic can be enhanced, the spectrum of the microbial effect broadened and even an antiviral effect can be obtained. Generally, the present invention can be exploited when there is a need for enhancement of the local antimicrobial effect of antibiotics.

Method of enhancing the antimicrobial action of systemically administered antibiotics

The invention relates to a mouthpiece and method for antibacterial treatment of intraoral surfaces. The mouthpiece comprises a body made of light-guiding material, the body comprising facial and lingual outer surfaces and facial and lingual inner surfaces adapted to face facial and lingual surfaces of teeth, respectively. A light source is attached to the body and adapted to deliver light to surfaces of teeth, the light source being positioned on at least one of said outer surfaces and adapted to deliver said light via said inner surfaces to both the facial and lingual surfaces of the teeth, wherein a portion of light is adapted to travel through said body from the facial side to the lingual side, or vice versa.

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Espoo, Finland

Sakari Nikinmaa