Council of Scientific and Industrial Research

Piramal Life Sciences Limited

Piramal Healthcare Limited

Saji George

Girish Badrinath Mahajan

Koteppa Pari

Ram Asrey Vishwakarma

Asha Adrian Kulkarni-Almeida

Meenakshi Sivakumar

Chandrakant Govind Naik

Lisette D'Souza

Satish Namdeo Sawant

Prabha Devi

Becky Mary Thomas

Nidhi Tomar

Vijaya Phani Kumar Yemparala

Prafull Vasant Ranadive

Prabhu Dutt Satyanarayan Mishra

Sreekumar Sankaranarayanan Eyyammadichiyil

Rajan Mukund Panshikar

Sridevi Krishna

Zarine Eruch Patel

This invention relates to novel compounds obtained by fermentation of Myxobacteria strain (PM0670013/MTCC 5570). The present invention further relates to the processes for the production of the novel anti-inflammatory compounds, to the culture no. PM0670013 (MTCC 5570), and to pharmaceutical compositions containing compounds of the present invention as an active ingredient and its use in medicines for the treatment of inflammatory diseases or disorders mediated by proinflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-&#x3b1;) and/or interleukins such as IL-6, having anti-inflammatory activity The invention also includes all stereoisomeric forms of compounds of the present invention.

Anti-inflammatory compounds

This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula CHNOS; which is obtained by fermentation of the microorganism belonging tospecies (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging tospecies (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

Antibacterial compounds

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Mumbai, India

Saji George