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Sairam Pothukuchi

Sriram K Rajagopal

Ranjan Chakrabarti

Srinivas Nanduri

Sunilkumar Bhadramma Kochunarayana Pillai

Venkateswarlu Akella

Subrahmanyam Duvvuri

Mallikarjuna Rao Gutti

Jagapathi Raju Srivatsavayi

Trimurthulu Singavarapu

Venkat Reddy Thimmaipally

Srinivasa Sastry Rani

Venkateswara Rao Tadanki

Mallikarjuna Rao Chikka

Chiranjeevi Cheekati

A process for preparation of 4-fluoro-&#x3b1;-[2-methyl-1-oxopropyl]-&#x3b3;-oxo-N-&#x3b2;-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-&#x3b1;-[2-methyl-1-oxopropyl]-&#x3b3;-oxo-n-&#x3b2;-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-&#x3b3;-oxo-N-&#x3b2;-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature &#x2212;25&#xb0; C. to 50&#xb0; C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base.

Process for preparation of 4-fluoro-&#x3b1;-[2methyl-l-oxopropyl]-&#x3b3;-oxo&#x2014;N&#x2014;&#x3b2;-diphenylbenzene butane amide

Described are pharmaceutically acceptable salts of a compound of formula (I) its tautomeric forms, its stereoisomers or its polymorphs, which is obtained by treating the compound of formula (I) with an acid selected from the group consisting of hydrohalo acid selected from the group consisting of hydrochloric acid or hydrobromic acid, acetic acid; sulfuric acid, nitric acid, phosphoric acid, boric acid, perchloric acid, tartaric acid, maleic acid, citric acid, methanesulfonic acid, benzoic acid, ascorbic acid, salicylic acid and benzene sulfonic acid wherein Rrepresents substituted (C&#x2013;C) alkyl wherein the substituent(s) is selected from mono (C&#x2013;C) alkylamino or di (C&#x2013;C) alkylamino; Rrepresents hydroxy;

Pharmaceutically acceptable salts of 20(s)-camptothecins

The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).

Anticancer compounds: process for their preparation and pharmaceutical compositions containing them

Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them

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Hyderabad Telangana, India

Sairam Pothukuchi