University of Oklahoma

University of Texas System

Saikat Haldar

Robert H Cichewicz

Susan L Mooberry

Lin Du

April L Risinger

Andrew J Robles

Peter Houghton

Allison O Mattes

Jianlan You

Shikha Srivastava

Cyclic depsipeptide-class molecules, referred to herein as persephacins (including analogs thereof), having similarities to aureobasidin A, are described. The persephacins have antimicrobial activity, such as antifungal activity against a diverse range of clinically-relevant fungal pathogens, antiprotozoan parasite activity, and antibacterial activity, and can be used for example in treatments of difficult-to-treat ocular fungal infections at lower concentrations than natamycin. The active compounds may be combined with a secondary compound in a composition.

Antimicrobial peptides and methods of use

Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.

Altertoxin II as a selective inhibitor of Ewing family of tumor cells

Growing community of inventors

Norman, OK, United States of America

Saikat Haldar