Synthego Corporation

Sahil Joshi

Travis Maures

Reed Kelso

John Andrew Walker, Ii

Anastasia Kadina

Jared Carlson-Stevermer

Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to improve the efficacy of target binding and/or cleavage.

Stabilized CRISPR complexes

Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides.

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Somerville, MA, United States of America

Sahil Joshi