Pharmagra Labs, Inc.

Provectus Pharmaceuticals, Inc.

Sahadeva Reddy Damireddi

Peter Wyatt Newsome

Albert Roger Frisbee

Jared K Nelson

Kpakpo Ambroise Akue

Kpakpo Ambrioise Akue

Eric A Wachter

Timothy C Scott

Jamie Singer

Marlon Lutz

Kevin Babiak

J Robert Durrwachter

The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.

Method of synthesising sulforaphane

The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent. 

The present invention relates to a method of synthesizing sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesizing a stabilized complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent. 

The present invention relates to methods of isolating and purifying sulforaphane. More specifically, the present invention relates to methods of isolating and purifying sulforaphane from natural sources. The present invention also relates to methods of forming high purity complexes of sulforaphane with cyclodextrin.

Sulforaphane isolation and purification

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100&#xb0; C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

Process for the synthesis of 4,5,6,7-tetrachloro-3',6&#x2032;-dihydroxy-2&#x2032;, 4&#x2032;, 5&#x2032;7&#x2032;-tetraiodo-3H-spiro[isobenzofuran-1,9&#x2032;-xanthen]-3-one (Rose Bengal) and related xanthenes

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Brevard, NC, United States of America

Sahadeva Reddy Damireddi