Merck + Co., Inc.

Sagrario M Del Val

Otto D Hensens

Richard L Monaghan

Sheldon B Zimmerman

Jerrold M Liesch

Robert E Schwartz

Robert A Giacobbe

Kenneth E Wilson

Carol F Wichmann

Maria I Fernandez

George M Garrity

Thomas W Miller

Eugene L Dulaney

James E Flor

Mary E Valiant

Sara A Currie

James P Springer

James A Milligan

Cheryl Deriso

Deborah L Zink

Janet C Onishi

Dennis M Schmatz

Edward O Stapley

Leeyuan Huang

Henry Joshua

Yiu-kuen T Lam

Isabel Martin

Michael D Greenspan

Yu L Kong

Jack L Smith

Justo M Mata

Walter Rozdilsky

Frank L VanMiddlesworth

Maria T Matas

Mary Nallin

Marcia M Zweerink

Robert A Fromtling

David Hendlin

Robert A Giocobbe

An antibiotic agent produced by the cultivation of Dictyochaeta simplex is described. The compound has broad antifungal activity and antipneumocystis activity.

Antibiotic agent

Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

Novel HMG-CoA synthase inhibitors

Fermentation of a nutrient medium by a Hypomycetes fungus of the genus Memnoniella or Stachybotrys yields a product with a major component of structural formula I: ##STR1## which is an inositol monophosphate phosphatase inhibitor and thereby useful in the treatment of manic depression.

Drug for treating manic depression

An antifungal agent produced by cultivation of Zalerion arboricola is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.

Process for antifungal fermentation product

L-654,040 of the structure: ##STR1## is a novel antibacterial and isolated from the novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC.

Process for producing L-654,040, antibacterial agent

The novel organism Streptoverticillium synroense, strain MA6011, deposited at the ATCC under Accession No. ATCC 53699 produces a novel antibacterial of the structure: ##STR1##

Culture of Streptoverticillium synroense for producing an antibacterial

Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.

Antifungal agent

An antifungal agent produced by cultivation of a yet unidentified microorganism is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity. Its production and isolation are also described.

Antifungal fermentation product

The process for the manufacture of the compound of the general structural formula ##STR1## which is a 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitor and useful as an antihypercholesterolemic agent for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, and which is an antifungal agent is disclosed.

Process for the manufacture of an antifungal antihypercholesterolemic .beta

Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.

Process for the preparation of difficidin and derivative antibacterials

Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.

Difficidin and derivative antibacterials

Pathogens are controlled by concomitant contact with a phosphonomycin antibiotic and a bacteriostatic chemotherapeutic compound by separate or simultaneous administration. The combined action is especially advantageous in contacting resistant microorganisms and other microorganisms which are oridinarily not controlled by contact with the individual chemotherapeutic agents.

Synergistic combinations of phosphonomycin and bacteriostatic agents

Growing community of inventors

Madrid, Spain

Sagrario M Del Val