Chugai Seiyaku Kabushiki Kaisha

Genentech, Inc.

Saeko Tanaka

Masayoshi Oh-Eda

Hidenari Yamada

Jean Bender

Rumiko Wakayama

Kelby Lau

Tomonori Isoda

Hisahiro Tabuchi

Tomoya Sugiyama

Satoshi Tainaka

The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.

Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration

The present invention provides a method capable of producing a natural or recombinant protein at low cost. The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses a taurine transporter and has a transferred DNA encoding a desired polypeptide and thereby allowing the cell to produce the polypeptide. Hamster taurine transporter, a DNA encoding the same, a recombinant vector and a transformed cell are also provided.

Method for recombinant production of a desired polypeptide using a mammalian cell co-expressing a taurine transporter polypeptide

A polypeptide selected from the group consisting of: (1) a polypeptide having the amino acid sequence of SEQ ID NO: 1, and (2) a polypeptide having an amino acid sequence in which the third amino acid of the amino acid sequence of SEQ ID NO: 1 is substituted by another amino acid and having insulin-like growth factor 1 (IGF-1) activity; a DNA encoding said polypeptide; a vector containing said DNA; a host cell containing said vector; and a method for preparing a recombinant protein using said polypeptide.

Nucleic acids encoding hamster 1GF-1 proteins and methods thereof

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Tokyo, Japan

Saeko Tanaka