Shionogi Company Limited

Sae Matsumoto

Yuuji Kooriyama

Chiaki Fujikoshi

Shinji Suzuki

Yukio Tada

Tatsuhiko Ueno

Shuji Yonezawa

Yuusuke Tamura

Akihiro Hori

Terukazu Kato

Yuusuki Tamura

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, 

Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, a compound represented by the formula: 

Sulfur-containing heterocyclic derivative having Beta secretase inhibitory activity

This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; Rand Rare each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R, R, Rand Rare each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.;a pharmaceutically acceptable salt or solvate thereof,which is useful for treating diseases induced by production, secretion and/or deposition of amyloid &#x3b2; protein.

Aminodihydrothiazine derivatives substituted with a cyclic group

This invention provides a compound of the formula (I): 

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Osaka, Japan

Sae Matsumoto