Elektrofi, Inc.

Sadiqua Shadbar

Paul Brown

Chase Spenser Coffman

Lisa Liu

Daniel Benjamin Dadon

Chaitanya Sudrik

Lyndon Fitzgerald Charles, Jr

Shankul Vartak

Tyler L Carter

Lyndon Charles

James W Ivey

Yi Tang

Jason G Auer

Moin Khwaja

Paul F Herbert

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof

The present disclosure relates to methods that enable the continuous formation of droplets and dehydration of droplets to provide pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled continuous droplet formation and dehydration that produce circular particles having low internal void spaces comprising bioactive therapeutic biologies.

Methods of forming particles by continuous droplet formation and dehydration

The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.

Compositions and methods for the delivery of therapeutic biologics for treatment of disease

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Allston, MA, United States of America

Sadiqua Shadbar