University of California

Other

The Salk Institute for Biological Studies

Trogenex, Inc.

Devacell, Inc.

Sadik C Esener

Inanc Ortac

Mark Wang

Jian Yang

William C Trogler

Ashok V Krishnamoorthy

Mihrimah Ozkan

Hod Finkelstein

Davorka Messmer

Michael Benchimol

Erhan Polatkan Ata

Johan Ulrik Lind

Kristina K P Mitchell

Sangeeta N Bhatia

Gen Yong

Yossi Ronen

Gokce Yayla

Philippe J Marchand

Dennis A Carson

Yu-Hwa Lo

Wolfgang J Wrasidlo

Michael James Heller

Benjamin D Sullivan

Joseph Wang

Rajaram Krishnan

Kai Zhao

Michael J Heller

Joseph E Ford

Donald J Sirbuly

Osman Kibar

Peter M Rentzepis

Bradley T Messmer

Carrolee Barlow

Sing H Lee

Milan T Makale

Jonathan Clay Claussen

Daniel Kagan

Pengyue Wen

Matthias Gross

Bartu Ahiska

Thomas Hamelin

Niren Angle

Negin Mokhtari

James Cheng

Sifang You

Daniel M Hartmann

Mukanth Vaidyanathan

Aaron L Birkbeck

Jeffrey M Cable

Subramania Krishnakumar

Ya-San Yeh

Volkan H Ozguz

Chi Fan

Ibrahim Gokce Yayla

Gary C Marsden

Pierre Ambs

Kristopher Urquhart

H Sing Lee

Ajay Sapre

Ilsun Yoon

Haijiang Zhang

Michael Heller

Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.

Nanoscale coatings for encapsulation of biological entities

Disclosed is a delivery device for delivering a payload, including a biological, chemical or biochemical substance, to a subject. The delivery device has a nanoparticle loaded with the payload, and porous coating structure over the loaded nanoparticle to prevent the payload from escaping the delivery device, while also preserving the activity of the payload and increasing effective utilization of the payload. Also disclosed is a delivery device for delivering a payload, including a natural virus, recombinant virus, or engineered virus. Also disclosed is a delivery device that has a liposome loaded with the payload and a biocompatible surface coating over the loaded liposome. Also disclosed are methods of fabricating the delivery devices and methods of using the delivery devices in treating health conditions, such as cancer, or in diagnostic applications.

Nano-scale delivery device and uses thereof

Techniques, systems, and devices are disclosed for non-thermal cycling of polymerase chain reaction (PCR). In one aspect, a method for cycling PCR includes receiving an electrolytic fluid including ions, primers, polymerase enzymes, nucleotides, and a double-stranded nucleic acid in a fluid chamber having a first electrode and a second electrode, applying an electric field across the first and the second electrodes to generate a first pH level of the electrolytic fluid to denature the double-stranded nucleic acid to at least partial single strands, and applying a second electric field across the first and second electrodes to produce a second pH level of the electrolytic fluid, in which the second pH level enables binding of a polymerase enzyme and a primer with a corresponding segment of the single strands.

Non-thermal cycling for polymerase chain reaction

The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene transfer.

Hollow silica nanospheres and methods of making same

Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an internal layer structured to enclose a hollow interior region and include one or more holes penetrating through the internal layer, and an external layer formed of a porous material around the internal layer; and an enzyme contained within the interior region of the shell structure, the enzyme having entered the shell structure through the one or more holes and incapable of passing through the external layer, in which the pores are of a size that prevents the enzyme to pass through the pores while permitting substances smaller than the pore size to pass through the pores.

Enzyme-encapsulated nanoparticle platform

Methods, structures, devices and systems are disclosed for fabricating and implementing nanoparticles with hollow core and sealable holes. In one aspect, a nanoparticle device can includes a shell structure including at least two layers including an internal layer and an external layer, the internal layer structured to enclose a hollow interior region and include one or more holes penetrating the internal layer, the external layer is of a porous material and formed around the internal layer and sealing the one or more holes, and a substance contained within the hollow interior region, the substance incapable of passing through the external layer.

Multifunctional nanoparticle designs and applications

Techniques, devices and systems are disclosed for implementing acoustically triggered propulsion of nano- and micro-scale structures. In one aspect, an ultrasound responsive propulsion device includes a tube that includes one or more layers including an inner layer having an electrostatic surface, and an ultrasound-responsive substance coupled to the inner layer and configured to form gaseous bubbles in a fluid in response to an ultrasound pulse, in which the bubbles exit the tube to propel the tube to move in the fluid.

Acoustically triggered nano/micro-scale propulsion devices

Methods, structures, devices and systems are disclosed for implementing a fiber optic force sensing transducer. In one aspect, an exemplary fiber optic force sensing transducer device includes an optical fiber coated by at least one layer of a polyelectrolyte material that utilizes the movement of optical structures coupled to the external polyelectrolyte layer in an evanescent field produced by the optical fiber to detect forces imposing on the fiber. In one aspect, an optical sensing device includes an optical waveguide that internally guides light, one or more layers formed outside the optical waveguide within an evanescent field of the guided light in the optical waveguide, and one or more optical structures coupled to the one or more layers in the evanescent field to emit light based on interaction with the evanescent field to indicate a position of an optical structure relative to an external surface of the optical waveguide.

Ultra-sensitive force sensing based on evanescent light

Techniques and apparatus for using single photon avalanche diode (SPAD) devices in various applications.

Shallow-trench-isolation (STI)-bounded single-photon avalanche photodetectors

Vertical cavity semiconductor optical amplifiers for various photonic devices including all optical logic gate devices and oscillators, where such devices can be implemented to achieve various advantages, including Boolean inversion at high speeds, low power, workable noise margins for cascadability because of input output isolation, and easy of integration in large arrays.

Photonic devices based on vertical-cavity semiconductor optical amplifiers

Growing community of inventors

Solana Beach, CA, United States of America

Sadik C Esener